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Analysis of institutional authors

Fernandez, ManelAuthorFernández Lobato, MercedesCorresponding AuthorTorres Nuñez, SandraAuthorTorres SAuthor

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Review

Recent advances in practical methods for liver cell biology: A short overview

Publicated to:International Journal Of Molecular Sciences. 21 (6): E2027- - 2020-03-01 21(6), DOI: 10.3390/ijms21062027

Authors: Torres, S; Klein, S; Schierwagen, R; Uschner, FE; Trebicka, J; Abdullah, Z; Brol, MJ; Hellerbrand, C; Fernandez, M; Fiorotto, R; Königshofer, P; Reiberger, T; Liedtke, C; Lotersztajn, S; Nevzorova, YA; Tacke, F; Weiskirchen, R

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Abstract

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany.

Keywords

fibrogenesishepatic stellate cellshepatocellular cancerin vitro modelsBileBiliary epithelial-cellsCholine-deficient dietEndothelial growth-factorFibrogenesisFibrotic liverHepatic stellate cellsHepatocellular cancerHepatocytesIn vitro modelsMiceRat-liverRodent cholangiocytesSteatosis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Molecular Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 67/295, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.6, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-06, the following number of citations:

  • WoS: 10
  • Scopus: 12
  • Europe PMC: 6
  • OpenCitations: 11

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 59.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 59 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.75.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Austria; Denmark; France; Germany; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Torres Berlanga, Sandra) .

the author responsible for correspondence tasks has been Fernández Lobato, Mercedes.