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We thank the following authors for providing additional data or information not included in some original articles: I. Fradkin; J. Nota; F. Piras and H. Snyder. Dr. Fullana and Dr. Vieta have received support from the Spanish Ministry of Science and Innovation integrated into the Plan Nacional de I + D+I and co-financed by the ISCIII-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER). Dr Fullana: PI16/00144; PI 19/00272. Dr. Vieta: PI15/00283; PI18/00805. Dr. Fullana has also received support from the Alicia Koplowitz Foundation (AKOPLOWITZ18_002). Dr. Lazaro, Dr. Golberg, Dr. Soriano-Mas, and Dr. Vieta have received support from the Department of Health of the Generalitat de Catalunya (Pla Estrategic de Recerca i Innovacio en Salut, PERIS) (Dr. Lazaro and Dr. Soriano-Mas: SLT002/16249; Dr. Goldberg: SLT002/16/00254; Dr. Vieta; SLT006/17/00357). Dr. Vieta has also received support from the Instituto de Salud Carlos III; the CIBER of Mental Health (CIBERSAM); the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365), and the CERCA Programme.

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Diagnostic biomarkers for obsessive-compulsive disorder: A reasonable quest or ignis fatuus?

Publicat a:Neuroscience And Biobehavioral Reviews. 118 504-513 - 2020-11-01 118(), DOI: 10.1016/j.neubiorev.2020.08.008

Autors: Fullana, Miquel A; Abramovitch, Amitai; Via, Esther; Lopez-Sola, Clara; Goldberg, Ximena; Reina, Nuria; Fortea, Lydia; Solanes, Aleix; Buckley, Matthew J; Ramella-Cravaro, Valentina; Carvalho, Andre F; Tortella-Feliu, Miquel; Vieta, Eduard; Soriano-Mas, Carles; Lazaro, Luisa; Stein, Dan J; Fernandez de la Cruz, Lorena; Mataix-Cols, David; Radua, Joaquim

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Obsessive-compulsive disorder (OCD) has been associated with a wide range of biological and neurocognitive findings, which could assist in the search for biomarkers. We conducted an umbrella review of systematic reviews and meta-analyses to assess and grade the strength of the evidence of the association between OCD and several potential diagnostic biomarkers while controlling for several potential biases. Twenty-four systematic reviews and meta-analyses were included, comprising 352 individual studies, more than 10,000 individuals with OCD, and covering 73 potential biomarkers. OCD was significantly associated with several neurocognitive biomarkers, with varying degrees of evidence, ranging from weak to convincing. A number of biochemical, neurophysiological, and neuroimaging biomarkers also showed statistically significant, albeit weak, associations with OCD. Analyses in unmedicated samples (123 studies) weakened the strength of the evidence for most biomarkers or rendered them non-significant. None of the biomarkers seem to have sufficient sensitivity and specificity to become a diagnostic biomarker. A more promising avenue for future biomarker research in OCD might be the prediction of clinical outcomes rather than diagnosis.Copyright © 2020 Elsevier Ltd. All rights reserved.

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