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Rojas-Lechuga, María JesúsAutor o coautorMullol, JoaquimAutor o coautorAlobid, IsamAutor (correspondència)

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SNOT-22 in general population, a Spanish cohort study with an updated meta-analysis

Publicat a:Rhinology. 62 (6): 700-709 - 2024-01-01 62(6), DOI: 10.4193/rhin24.233

Autors: Pineros-Garcia, Lina M; Pineros-Garcia, Lina M; Gonzalez-Sanchez, Nesly I; Gonzalez-Sanchez, Nesly I; Calvo-Henriquez, Christian; Rojas-Lechuga, Maria Jesus; Hopkins, Claire; Mullol, Joaquim; Alobid, Isam

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Background: The SNOT-22 is a questionnaire that evaluates the impact of chronic rhinosinusitis (CRS) on the patient's quality of life. This calculation allows measures to define therapeutic strategies and to estimate the response to treatment. Therefore, having this measure in the general population allows to establish normal values to guide decision-making in clinical practice. The objective was to determine the SNOT-22 score in a general Spanish population without CRS, according to gender, age, and comorbidities and to perform a systematic review of the literature and a meta-analysis. Methods: The SNOT-22 questionnaire was used to evaluate whether demographic factors, smoking habits, or comorbidities can influence the score in the general population. A systematic literature review was performed to identify studies where the SNOT-22 questionnaire was applied in a population without CRS. Results: 289 patients were included in the study (170 women), mean age 46.6 (17.8) years, range 18-89. No statistically significant difference between age subgroups (18-30, 31-50. 51-70, >70 years). The mean SNOT-22 was 11.9 (14.6), with no difference between genders. There was a positive association between obstructive sleep apnea (OSA) and anxiety-depression, with a higher SNOT-22 score. The metanalysis included 23 studies (3500 participants), with a mean value 10.52 under fixed effects model. Conclusion: This study has defined the normal value of the SNOT-22 questionnaire in the general Spanish population without gender-based differences. The included studies had demonstrated homogeneity, despite being performed in different populations. Conditions such as anxiety/depression and sleep apnea increase baseline SNOT-22 scores.

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