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Grant support

This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2012-31220 to RA) and the Government of Catalonia (SRG2009-1526).

Analysis of institutional authors

Pujol, M JAuthorBachs, OAuthorAligue, RCorresponding Author
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Article

Ssp1 CaMKK: A Sensor of Actin Polarization That Controls Mitotic Commitment through Srk1 in Schizosaccharomyces pombe

Publicated to:Plos One. 10 (11): e0143037- - 2015-11-17 10(11), DOI: 10.1371/journal.pone.0143037

Authors: Gómez-Hierro A, Lambea E, Giménez-Zaragoza D, López-Avilés S, Yance-Chávez T, Montserrat M, Pujol MJ, Bachs O, Aligue R

Affiliations

Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain - Author
The Biotechnology Centre of Oslo, Cell Cycle Regulation, Oslo, Norway - Author
Biotechnol Ctr Oslo, Cell Cycle Regulat, Oslo, Norway - Author
Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain - Author
Univ Barcelona, Fac Med, Dept Biol Cellular Immunol & Neurociencies, Inst Biomed Res August Pi & Sunyer IDIBAPS, Barcelona 7, Catalunya, Spain - Author
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Abstract

Calcium/calmodulin-dependent protein kinase kinase (CaMKK) is required for diverse cellular functions. Mammalian CaMKK activates CaMKs and also the evolutionarily-conserved AMP-activated protein kinase (AMPK). The fission yeast Schizosaccharomyces pombe CaMKK, Ssp1, is required for tolerance to limited glucose through the AMPK, Ssp2, and for the integration of cell growth and division through the SAD kinase Cdr2.Here we report that Ssp1 controls the G2/M transition by regulating the activity of the CaMK Srk1. We show that inhibition of Cdc25 by Srk1 is regulated by Ssp1; and also that restoring growth polarity and actin localization of ssp1-deleted cells by removing the actin-monomer-binding protein, twinfilin, is sufficient to suppress the ssp1 phenotype.These findings demonstrate that entry into mitosis is mediated by a network of proteins, including the Ssp1 and Srk1 kinases. Ssp1 connects the network of components that ensures proper polarity and cell size with the network of proteins that regulates Cdk1-cyclin B activity, in which Srk1 plays an inhibitory role.

Keywords
cell-divisioncyclefission yeastformin for3pgrowth polaritylocalizationserine/threonine kinasestress-responsetwinfilinActivated protein-kinase

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plos One due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2015, it was in position 11/62, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-09:

  • WoS: 6
  • Scopus: 5
  • Europe PMC: 5
  • OpenCitations: 7
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 25.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 25 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.75.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Norway.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Gomez-Hierro, A) and Last Author (Aligué Alemany, Rosa).

the author responsible for correspondence tasks has been Aligué Alemany, Rosa.