{rfName}
In

Indexed in

License and use

Citations

17

Altmetrics

Grant support

Dr. Rodriguez-Sureda is supported by the Centre for Biomedical Network Research on Rare Diseases (CIBERER) from Instituto de Salud Carlos III. The study was supported in part by grants from Fondo de Investigaciones Sanitarias (FIS PI12/00851 and FIS PI13/01449). The samples used in this Project were provided by the Hospital Clinic-IDIBAPS Biobank and Biobanc HUVH with an appropiate ethical approval. We are grateful to Miss C. O'Hara for her help in editing the English language in the original manuscript.

Analysis of institutional authors

Rodriguez-Sureda, VCorresponding AuthorCrovetto, FAuthorTriunfo, SAuthorCrispi, FAuthorGratacos, EAuthorFigueras, FAuthor
Share
Publications
>
Article

Increased secretory sphingomyelinase activity in the first trimester of pregnancy in women later developing preeclampsia: a nested case-control study

Publicated to:Biological Chemistry. 397 (3): 269-279 - 2016-03-01 397(3), DOI: 10.1515/hsz-2015-0266

Authors: Rodriguez-Sureda, Victor; Crovetto, Francesca; Triunfo, Stefania; Sanchez, Olga; Crispi, Fatima; Llurba, Elisa; Gratacos, Eduard; Figueras, Francesc; Dominguez, Carmen

Affiliations

Hosp Univ Vall dHebron, Biochem & Mol Biol Res Ctr Nanomed, Pg La Vall dHebron 119-129, E-08035 Barcelona, Spain - Author
Inst Salud Carlos III, Ctr Biomed Res Rare Dis CIBERER, E-08035 Barcelona, Spain - Author
Inst Salud Carlos III, Maternal & Child Hlth & Dev Network SAMID II 2, E-08035 Barcelona, Spain - Author
Policlin Univ Milano, Osped Maggiore, Dept Obstet & Gynecol, Fdn Ca Granda, I-20122 Milan, Italy - Author
Univ Barcelona, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Hosp Clin, E-08028 Barcelona, Spain - Author
Univ Barcelona, IDIBAPS, Hosp St Joan de Deu, E-08028 Barcelona, Spain - Author
See more

Abstract

The pathogenic basis of abnormal placentation and dysfunction in preeclampsia (PE) is highly complex and incompletely understood. Secretory sphyngomyelinase activity (S-ASM) was analyzed in plasma samples from 158 pregnant women developing PE and 112 healthy pregnant controls. Serum PlGF, sFlt-1, s-Endoglin and sVCAM were measured. Results showed S-ASM activity to be higher in women who later developed PE than in those with uncomplicated pregnancies (40.6% and 28.8% higher in the late- and early-onset groups, respectively). Plasma S-ASM activity correlated significantly with circulating markers of endothelial damage in the late-PE group (endoglin and sVCAM-1), with plasma cholesterol and total lipid levels. However, these significant associations were not observed in the early-PE or control groups. This work provides the first evidence of significantly elevated circulating S-ASM activity in the first trimester of pregnancy in women who go on to develop PE; thus, it may be deduced that the circulating form of ASM is biologically active in PE and could contribute to promoting endothelial dysfunction and cardiovascular programming. Plasma S-ASM measurement may have clinical relevance as a further potential biomarker contributing to the earliest identification of women at risk of developing preeclampsia.

Keywords
adhesion moleculesangiogenic factorsearly-onsetendothelial-cellsfirst-trimester of pregnancygrowth-factorhuman acid sphingomyelinaselipidsoxidative stressplasmapreeclampsiasecretory acid sphingomyelinase (s-asm)soluble endoglinvcamAdhesion moleculesAdultAngiogenic factorsAntigens, cdBiomarkersCase-control studiesEndoglinEndothelial-cellsEng protein, humanFemaleFirst-trimester of pregnancyFlt1 protein, humanHuman acid sphingomyelinaseHumansIntrauterine growth restrictionLipidsMembrane proteinsOnset preeclampsiaOxidative stressPigf protein, humanPre-eclampsiaPreeclampsiaPregnancyPregnancy trimester, firstReceptors, cell surfaceSecretory acid sphingomyelinase (s-asm)SerumSoluble endoglinSphingomyelin phosphodiesteraseUterine artery dopplerVascular cell adhesion molecule-1Vascular endothelial growth factor receptor-1Vcam

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biological Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2016, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Biochemistry.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-11:

  • WoS: 6
  • Scopus: 7
  • Europe PMC: 4
  • OpenCitations: 6
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-11:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 28.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 28 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Rodríguez Sureda, Víctor) .

the author responsible for correspondence tasks has been Rodríguez Sureda, Víctor.