{rfName}
As

Indexed in

License and use

Icono OpenAccess

Altmetrics

Grant support

The authors thank Dr. F. Michetti, (Istituto di Anatomia Umana e Biologia Cellulare, Universita Cattolica del Sacro Cuore) for valuable advice and discussion of results during this study. This work was supported by Grant IPT-2012-0614-010000 from the Ministerio de Economia y Competitividad (Spain).

Analysis of institutional authors

Batlle, MAuthorAndrade, CarmenAuthorMahy, NicoleAuthorRodriguez, Manuel J.Corresponding Author

Share

Publications
>
Article

Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus

Publicated to:Biomed Research International. 2015 (102419): 102419- - 2015-01-01 2015(102419), DOI: 10.1155/2015/102419

Authors: Batlle, Montserrat; Ferri, Lorenzo; Andrade, Carmen; Ortega, Francisco-Javier; Vidal-Taboada, Jose M.; Pugliese, Marco; Mahy, Nicole; Rodriguez, Manuel J.;

Affiliations

Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona 08036, Spain - Author
Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Fac Med, Unitat Bioquim & Biol Mol, E-08036 Barcelona, Spain - Author
Univ Cattolica Sacro Cuore, Fac Med & Chirurg, Ist Anat Umana & Biol Cellulare, I-00168 Rome, Italy - Author
VHIR, Barcelona 08035, Spain - Author

Abstract

Brain injury triggers a progressive inflammatory response supported by a dynamic astroglia-microglia interplay. We investigated the progressive chronic features of the astroglia-microglia cross talk in the perspective of neuronal effects in a rat model of hippocampal excitotoxic injury. N-Methyl-D-aspartate (NMDA) injection triggered a process characterized within 38 days by atrophy, neuronal loss, and fast astroglia-mediated S100B increase. Microglia reaction varied with the lesion progression. It presented a peak of tumor necrosis factor-? (TNF-?) secretion at one day after the lesion, and a transient YM1 secretion within the first three days. Microglial glucocorticoid receptor expression increased up to day 5, before returning progressively to sham values. To further investigate the astroglia role in the microglia reaction, we performed concomitant transient astroglia ablation with L-?-aminoadipate and NMDA-induced lesion. We observed a striking maintenance of neuronal death associated with enhanced microglial reaction and proliferation, increased YM1 concentration, and decreased TNF-? secretion and glucocorticoid receptor expression. S100B reactivity only increased after astroglia recovery. Our results argue for an initial neuroprotective microglial reaction, with a direct astroglial control of the microglial cytotoxic response. We propose the recovery of the astroglia-microglia cross talk as a tissue priority conducted to ensure a proper cellular coordination that retails brain damage.

Keywords

accumulationactivationastrocytesexpressionischemialocalizationmodelproliferations100bAnimalsAstrocytesBeta-n-acetylhexosaminidasesBrainCell proliferationExcitotoxicityExpressionGene expressionHippocampusInjuryMicrogliaModelMultiple-sclerosisN-methylaspartateNerve degenerationNeuronsProliferationRatsReceptors, glucocorticoidS100 calcium binding protein beta subunitS100bTnf-alphaTumor necrosis factor-alpha

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biomed Research International due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2015, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Biotechnology & Applied Microbiology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.67. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 3.99 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-26, the following number of citations:

  • WoS: 48
  • Scopus: 24
  • Europe PMC: 15
  • OpenCitations: 23

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-26:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 62.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 64 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 10.25.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Batlle Lacort, Marta) and Last Author (Rodriguez Allue, Manuel Jose).

the author responsible for correspondence tasks has been Rodriguez Allue, Manuel Jose.