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Analysis of institutional authors

Spatola MAuthorPetit-Pedrol MAuthorArmangue TAuthorRosenfeld MrAuthorGraus FAuthorDalmau JCorresponding Author

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Investigations in GABAA receptor antibody-associated encephalitis.

Publicated to:Neurology. 88 (11): 1012-1020 - 2017-03-14 88(11), DOI: 10.1212/wnl.0000000000003713

Authors: Spatola, Marianna; Petit-Pedrol, Mar; Simabukuro, Mateus Mistieri; Armangue, Thas; Castro, Fernanda J; Barcelo Artigues, Maria I; Julia Benique, Maria R; Benson, Leslie; Gorman, Mark; Felipe, Ana; Oblitas, Ruben L Caparo; Rosenfeld, Myrna R; Graus, Francesc; Dalmau, Josep

Affiliations

Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain - Author
Childrens Hosp, Dept Neurol, Boston, MA USA      Harvard University - Author
CIBERER, Madrid, Spain.      CIBERER    CIBER - Centro de Investigacion Biomedica en Red - Author
CIBERER, Madrid, Spain      CIBERER    CIBER - Centro de Investigacion Biomedica en Red - Author
Hosp Base, Brasilia, DF, Brazil - Author
Hosp Clin Barcelona, Serv Neurol, Barcelona, Spain.      Hospital Clinic de Barcelona    University of Barcelona - Author
Hosp Clin Barcelona, Serv Neurol, Barcelona, Spain      Hospital Clinic de Barcelona    University of Barcelona       - Author
Hosp Nacl Edgardo Rebagliati Martins, Lima, Peru - Author
Hosp St Joan Deu, Neurol Serv, Barcelona, Spain.      University of Barcelona - Author
Hosp St Joan Deu, Neurol Serv, Barcelona, Spain      University of Barcelona - Author
Univ Barcelona, IDIBAPS, E-08007 Barcelona, Spain.      University of Barcelona    Hospital Clinic de Barcelona    IDIBAPS - Author
Univ Barcelona, IDIBAPS, E-08007 Barcelona, Spain      IDIBAPS    University of Barcelona    Hospital Clinic de Barcelona - Author
Univ Hosp Son Espases, Serv Immunol, Mallorca, Spain      Hospital Universitario Son Espases - Author
Univ Hosp Son Espases, Serv Neurol, Mallorca, Spain      Hospital Universitario Son Espases - Author
Univ Lausanne UNIL, Lausanne, Switzerland      University of Lausanne - Author
Univ Penn, Dept Neurol, Philadelphia, PA USA.      University of Pennsylvania - Author
Univ Penn, Dept Neurol, Philadelphia, PA USA      University of Pennsylvania - Author
Univ Sao Paulo, Hosp Clin, Div Neurol, Sao Paulo, Brazil      Universidade de Sao Paulo       - Author
Vall Hebron Univ Hosp, Pediat Neurol Sect, Barcelona, Spain      Hospital Universitari Vall d'Hebron       - Author
      Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain. - Author
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Abstract

To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA receptor (GABAAR) encephalitis.Clinical study of 26 patients, including 17 new (April 2013-January 2016) and 9 previously reported patients. Antibodies to ?1, ?3, and ?2 subunits of the GABAAR were determined using reported techniques.Patients' median age was 40.5 years (interquartile range 48.5 [13.75-62.35] years; the youngest 2.5 months old; 13 female). Symptoms included seizures (88%), alteration of cognition (67%), behavior (46%), consciousness (42%), or abnormal movements (35%). Comorbidities were identified in 11 (42%) patients, including 7 tumors (mostly thymomas), 2 herpesvirus encephalitis (herpes simplex virus 1, human herpesvirus 6; coexisting with NMDAR antibodies), and 2 myasthenia without thymoma. Brain MRI was abnormal in 23 (88%) patients, showing in 20 (77%) multifocal, asynchronous, cortical-subcortical T2/fluid-attenuated inversion recovery abnormalities predominantly involving temporal (95%) and frontal (65%) lobes, but also basal ganglia and other regions. Immunologic or tumor therapy resulted in substantial improvement in 18/21 (86%) assessable patients; the other 3 (14%) died (2 status epilepticus, 1 sepsis). Compared with adults, children were more likely to have generalized seizures (p = 0.007) and movement disorders (p = 0.01) and less likely to have a tumor (p = 0.01). The main epitope targets were in the ?1/?3 subunits of the GABAAR.Anti-GABAAR encephalitis is characterized by frequent seizures and distinctive multifocal cortical-subcortical MRI abnormalities that provide an important clue to the diagnosis. The frequency of symptoms and comorbidities differ between children (more viral-related) and adults (more tumor-related). The disorder is severe but most patients respond to treatment.© 2017 American Academy of Neurology.

Keywords

absence epilepsycase seriesgamma-2-subunitmutationseizurestransplantationAdolescentAdultAnimalsAntibodiesAutoimmune encephalitisBrainCognition disordersConsciousnessEncephalitisFemaleHek293 cellsHumansImmunotherapyMagnetic resonance imagingMaleMiddle agedMovement disordersRatsReceptors, gaba-aRetrospective studiesSeizuresTransfectionYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Neurology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 13/197, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 7.18. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 9.11 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 71.13 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-01, the following number of citations:

  • WoS: 203
  • Scopus: 267
  • Europe PMC: 96

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 266.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 266 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 48.85.
  • The number of mentions on the social network Facebook: 3 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 55 (Altmetric).
  • The number of mentions on Wikipedia: 3 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Brazil; Peru; Switzerland; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Spatola, Marianna) and Last Author (Dalmau Obrador, Josep).

the author responsible for correspondence tasks has been Dalmau Obrador, Josep.