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Artigas Perez, FrancescAuthorCelada Pedrosa, María PazAuthorRiga, MaurizioAuthor

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January 8, 2018
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The serotonin hallucinogen 5-MeO-DMT alters cortico-thalamic activity in freely moving mice: Regionally-selective involvement of 5-HT1Aand 5-HT2Areceptors

Publicated to:Neuropharmacology. 142 219-230 - 2018-11-01 142(), DOI: 10.1016/j.neuropharm.2017.11.049

Authors: Riga, Maurizio S; Llado-Pelfort, Laia; Artigas, Francesc; Celada, Pau

Affiliations

CIBERSAM Ctr Invest Biomed Red Salud Mental, Madrid, Spain - Author
CSIC IDIBAPS, Inst Invest Biomed Barcelona, Dept Neurochem & Neuropharmacol, Barcelona, Spain - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain - Author

Abstract

5-MeO-DMT is a natural hallucinogen acting as serotonin 5-HT1A/5-HT2A receptor agonist. Its ability to evoke hallucinations could be used to study the neurobiology of psychotic symptoms and to identify new treatment targets. Moreover, recent studies revealed the therapeutic potential of serotonin hallucinogens in treating mood and anxiety disorders. Our previous results in anesthetized animals show that 5-MeO-DMT alters cortical activity via 5-HT1A and 5-HT2A receptors. Here, we examined 5-MeO-DMT effects on oscillatory activity in prefrontal (PFC) and visual (V1) cortices, and in mediodorsal thalamus (MD) of freely-moving wild-type (WT) and 5-HT2A-R knockout (KO2A) mice. We performed local field potential multi-recordings evaluating the power at different frequency bands and coherence between areas. We also examined the prevention of 5-MeO-DMT effects by the 5-HT1A-R antagonist WAY-100635. 5-MeO-DMT affected oscillatory activity more in cortical than in thalamic areas. More marked effects were observed in delta power in V1 of KO2A mice. 5-MeO-DMT increased beta band coherence between all examined areas. In KO2A mice, WAY100635 prevented most of 5-MeO-DMT effects on oscillatory activity. The present results indicate that hallucinatory activity of 5-MeO-DMT is likely mediated by simultaneous alteration of prefrontal and visual activities. The prevention of these effects by WAY-100635 in KO2A mice supports the potential usefulness of 5-HT1A receptor antagonists to treat visual hallucinations. 5-MeO-DMT effects on PFC theta activity and cortico-thalamic coherence may be related to its antidepressant activity. This article is part of the Special Issue entitled 'Psychedelics: New Doors, Altered Perceptions'.Copyright © 2017. Published by Elsevier Ltd.

Keywords

5-ht receptors5-ht(1a) receptor5-ht(2a) receptor5-ht1a receptor5-ht2a receptor5-meo-dmtantipsychotic-drugscortico-thalamic activitygabaergic neuronshallucinogenshuman-brainin-vivolocomotor-activitymood-regulating circuitoscillatory activitypreferential actionprepulse inhibitionpyramidal neuronsrat prefrontal cortexsensorial cortical areasserotonin(2a) receptorsventral tegmental areavisual cortexvisual-cortex5-ht receptor 1a5-ht receptor 2a5-ht receptor 1a5-ht receptor 2a5-ht(1a) receptor5-ht(2a) receptor5-meo-dmtAnimalsBrain wavesCortico-thalamic activityHallucinogensHtr1a protein, mouseHtr2a protein, mouseMaleMedial prefrontal cortexMethoxydimethyltryptaminesMice, inbred c57blMice, knockoutN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyclohexanecarboxamidePiperazinesPrefrontal cortexPsychoactive beverage ayahuascaPyridinesReceptor, serotonin, 5-ht1aReceptor, serotonin, 5-ht2aSerotonin antagonistsSerotonin hallucinogensSerotonin receptor agonistsThalamusVisual cortex

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Neuropharmacology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position 40/267, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.61. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 7.45 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 49
  • Scopus: 9
  • Europe PMC: 24
  • Google Scholar: 39

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 121.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 133 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.25.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).