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Rodríguez Ferret, NataliaAuthorPlana, Maria TeresaCorresponding AuthorTorres TAuthorRodriguez NAuthorBoloc DAuthorGasso PAuthorMoreno EAuthorLafuente AAuthorCastro-Fornieles JAuthorMas SAuthorLazaro LCorresponding Author
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Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder

Publicated to:Psychiatry Research. 271 554-558 - 2019-01-01 271(), DOI: 10.1016/j.psychres.2018.12.019

Authors: Teresa Plana, Maria; Torres, Teresa; Rodriguez, Natalia; Boloc, Daniel; Gasso, Patricia; Moreno, Elena; Lafuente, Amalia; Castro-Fornieles, Josefina; Mas, Sergi; Lazaro, Luisa

Affiliations

August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain - Author
Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain - Author
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Spain. - Author
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Spain. Electronic address: llazaro@clinic.cat. - Author
Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, C/ Villarroel 170, E-08036 Barcelona, Spain - Author
Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, C/ Villarroel 170, E-08036 Barcelona, Spain. - Author
Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, C/ Villarroel 170, E-08036 Barcelona, Spain. Electronic address: sergimash@ub.edu. - Author
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain - Author
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain. - Author
Department of Medicine, University of Barcelona, Barcelona, Spain - Author
Department of Medicine, University of Barcelona, Barcelona, Spain. - Author
Hosp Clin Barcelona, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, C Villarroel 170, E-08036 Barcelona, Spain - Author
The August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain - Author
The August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. - Author
Univ Barcelona, Dept Med, Barcelona, Spain - Author
Univ Barcelona, Pharmacol Unit, Dept Clin Fdn, Barcelona, Spain - Author
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Abstract

The age of onset of some psychiatric disorders may have etiopathogenic and clinical effects and may influence outcome. Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset. One hundred and sixteen adolescents diagnosed with AN and 74 adolescents diagnosed with OCD participated in the present study. We confirmed the existence of a genetic overlap between OCD and AN. Specifically, we described genetic pleiotropy for age at onset across these disorders, associating two SNPs (rs6311, rs4942587) of the HTR2A with the very-early onset phenotype.Copyright © 2018 Elsevier B.V. All rights reserved.

Keywords
adolescentsage of onsetanorexia nervosaanxiety disordersassociationchildreneating-disordersfamilygenetic pleiotropyobsessive-compulsive disorderpersonality-disordersscrotonin: 5htr2aserotonin: 5htr2asingle nucleotide polymorphisms5-ht2a promoter polymorphismAdolescentAdolescentsAge of onsetAnorexia nervosaAnxiety disordersAssociationChildChildrenEating-disordersFamilyFemaleGenetic pleiotropyHumansMaleObsessive-compulsive disorderPersonality-disordersPhenotypePolymorphism, single nucleotideScrotonin: 5htr2aSerotonin plasma membrane transport proteinsSerotonin: 5htr2aSingle nucleotide polymorphismsTryptophan hydroxylaseVesicular monoamine transport proteins

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Psychiatry Research due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Psychiatry and Mental Health.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.14, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-12, the following number of citations:

  • WoS: 11
  • Scopus: 12
  • Europe PMC: 4
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 59.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 59 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.5.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Lázaro García, Luisa).

the authors responsible for correspondence tasks have been Plana Turró, Maria Teresa and Lázaro García, Luisa.