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Analysis of institutional authors

Vila Martos, GemmaAuthorVilloslada PCorresponding AuthorVila GAuthorColafrancesco VAuthorMoreno BAuthorFernandez-Diez BAuthorVazquez RAuthorPertsovskaya IAuthorZubizarreta IAuthor

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Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation

Publicated to:Neurotherapeutics. 16 (3): 808-827 - 2019-07-15 16(3), DOI: 10.1007/s13311-019-00717-4

Authors: Villoslada, Pablo; Vila, Gemma; Colafrancesco, Valeria; Moreno, Beatriz; Fernandez-Diez, Begona; Vazquez, Raquel; Pertsovskaya, Inna; Zubizarreta, Irati; Pulido-Valdeolivas, Irene; Messeguer, Joaquin; Vendrell-Navarro, Gloria; Maria Frade, Jose; Lopez-Sanchez, Noelia; Teixido, Meritxell; Giralt, Ernest; Masso, Mar; Dugas, Jason C; Leonoudakis, Dmitri; Lariosa-Willingham, Karen D; Steinman, Lawrence; Messeguer, Angel

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Abstract

© 2019, The American Society for Experimental NeuroTherapeutics, Inc. The development of neuroprotective therapies is a sought-after goal. By screening combinatorial chemical libraries using in vitro assays, we identified the small molecule BN201 that promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors. Moreover, BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes in vitro, and the myelination of new axons. BN201 modulates several kinases participating in the insulin growth factor 1 pathway including serum–glucocorticoid kinase and midkine, inducing the phosphorylation of NDRG1 and the translocation of the transcription factor Foxo3 to the cytoplasm. In vivo, BN201 prevents axonal and neuronal loss, and it promotes remyelination in models of multiple sclerosis, chemically induced demyelination, and glaucoma. In summary, we provide a new promising strategy to promote neuroaxonal survival and remyelination, potentially preventing disability in brain diseases.

Keywords

barrierbetaexperimental autoimmune encephalomyelitisexpressionglaucomamethylthioadenosinemidkinemodelsmultiple sclerosisneurodegenerative diseasesneuroinflammationneuroprotectionserumsgk1AmidesAnimalsAxonsBarrierBetaCycloguanilDisease models, animalEncephalitisEncephalomyelitis, autoimmune, experimentalExperimental autoimmune encephalomyelitisExpressionFemaleFluorescent antibody techniqueGlaucomaGlucocorticoid-inducible kinaseMaleMethylthioadenosineMiceMice, inbred c57blMidkineModelsMultiple sclerosisMyelin sheathNeurodegenerative diseasesNeuroinflammationNeuroprotectionNeuroprotective agentsOptic nervePeptoidsProguanilPyrrolidinonesRatsRats, sprague-dawleyReal-time polymerase chain reactionSerumSgk1Triazines

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Neurotherapeutics due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 18/271, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.17, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-07, the following number of citations:

  • WoS: 8
  • Scopus: 9
  • Europe PMC: 5
  • Google Scholar: 8
  • OpenCitations: 10

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-07:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 43.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 43 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 13.45.
  • The number of mentions on the social network X (formerly Twitter): 15 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Villoslada Diaz, Pablo) .

the author responsible for correspondence tasks has been Villoslada Diaz, Pablo.