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Barberan-Garcia ACorresponding AuthorGimeno-Santos EAuthorBurgos FAuthorTorralba YAuthorGistau CAuthorRoca JCorresponding AuthorRodríguez DAuthor

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Training-induced changes on quadriceps muscle oxygenation measured by near-infrared spectroscopy in healthy subjects and in chronic obstructive pulmonary disease patients

Publicated to:Clinical Physiology And Functional Imaging. 39 (4): 284-290 - 2019-07-01 39(4), DOI: 10.1111/cpf.12572

Authors: Barberan-Garcia, Anael; Munoz, Phillip A; Gimeno-Santos, Elena; Burgos, Felip; Torralba, Yolanda; Gistau, Concepcion; Roca, Josep; Rodriguez, Diego A

Affiliations

Royal Prince Alfred Hosp, Resp Invest Unit, Resp & Sleep Med, Camperdown, NSW, Australia - Author
Royal Prince Alfred Hospital - Author
Univ Barcelona, Hosp Clin Barcelona, Resp Med Dept, IDIBAPS,CIBERES, Barcelona, Spain - Author
Univ Pompeu Fabra, Hosp del Mar, Pulmonol Dept, Inst Hosp Mar Invest Med IMIM,CIBERES ISCIII, Barcelona, Spain - Author
Universitat de Barcelona - Author
Universitat Pompeu Fabra Barcelona - Author
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Abstract

© 2019 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd Aim: We hypothesize that training-induced changes in muscle oxygen saturation (StO 2 ) assessed by near-infrared spectroscopy (NIRS) during constant work rate cycling exercise (CWRE) may be a useful marker of the effects of training at ‘vastus medialis’ of the quadriceps in patients with chronic obstructive pulmonary disease (COPD). Methods: Incremental exercise [peak oxygen uptake (VO 2 )] and CWRE at 70% pretraining peak VO 2 , before and after 8-w training, were done in 10 healthy age-matched subjects (H) [80% men, 65(11) years, FEV 1 105(14)%] and 16 COPD patients [94% men, 70(5) years, FEV 1 46(11) %] encompassing the entire spectrum of disease severity, recruited in the outpatient clinics. NIRS was used to assess StO 2 in the ‘vastus medialis’ of the left quadriceps. Results: Pretraining CWRE decreased StO 2 (P<0·05) and generated marked StO 2 rebound (P<0·001) after unloading in the two groups. After training, VO 2 peak increased in H [253(204) ml min −1 ] (P<0·01) and in COPD [180(183) ml·min −1 ] (P = 0·01) and blood lactate fell [−4·4 (2·7) and −1·6(2·3) mmol·m −1 ] (P<0·05 each). Training generated a further fall in StO 2 during CWRE [−10(12)% and −10(10)%, P<0·05] and increased StO 2 rebound after unloading [8(7)% and 5(9)%, P<0·05] in both groups. Conclusion: Endurance training further decreased StO 2 during CWRE, similarly in both groups, likely due to training-induced enhancement of muscle O 2 transfer and utilization. Training-induced StO 2 fall during CWRE may be useful individual marker for non-invasive assessment of enhanced muscle aerobic post-training function.

Keywords

deoxygenationdysfunctionexerciseexercise testingexercise trainingmetabolismmuscle oxygen saturationnirsoxidative capacityphotonicssaturationstatementuptake kineticsAgedCase-control studiesExercise testingExercise toleranceExercise trainingFemaleHealth statusHumansMaleMiddle agedMuscle oxygen saturationOxygen consumptionPhotonicsPredictive value of testsProspective studiesPulmonary disease, chronic obstructiveQuadriceps muscleSeverity of illness indexSkeletal-muscleSpectroscopy, near-infrared

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical Physiology And Functional Imaging due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned en el Cuartil Q4 for the agency WoS (JCR) in the category Physiology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.18, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-16, the following number of citations:

  • WoS: 9
  • Scopus: 9
  • Europe PMC: 6
  • OpenCitations: 10

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 84.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 84 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.95.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Australia.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Barberan Garcia, Anael) and Last Author (Rodriguez Bruna, David).

the authors responsible for correspondence tasks have been Barberan Garcia, Anael and Roca Torrent, Josep.