{rfName}
Hi

Indexed in

License and use

Citations

46

Altmetrics

Analysis of institutional authors

Ribal, MjAuthorAlcaraz, AAuthor

Share

Publications
>
Article

Higher sex hormone-binding globulin and lower bioavailable testosterone are related to prostate cancer detection on prostate biopsy

Publicated to:Scandinavian Journal Of Urology. 47 (4): 282-289 - 2013-08-01 47(4), DOI: 10.3109/00365599.2012.747562

Authors: Garcia-Cruz, Eduardo; Carrion Puig, Albert; Garcia-Larrosa, Alejandro; Sallent, Andrea; Castaneda-Argaiz, Roberto; Piqueras, Marta; Ribal, Maria Jose; Leibar-Tamayo, Asier; Romero-Otero, Javier; Alcaraz, Antonio

Affiliations

Hosp 12 Octubre, Madrid, Spain - Author
Hosp Clin Barcelona, Dept Urol, E-08036 Barcelona, Spain - Author
Hosp Galdakao, Bilbao, Spain - Author
Hosp Viladecans, Barcelona, Spain - Author
Hospital 12 de Octubre, Madrid, Spain - Author
Hospital de Viladecans, Barcelona, Spain - Author
Hospital Galdakao, Bilbao, Spain - Author
Red Española de Investigación en Salud del Hombre (REISHO), Spain - Author
Urology Department, Hospital Clinic de Barcelona, 170 Villarroel st, 08036 Barcelona, Spain - Author
See more

Abstract

Recent studies show an inverse relationship between testosterone levels and prostate cancer (PCa). The usefulness of hormonal patterns in PCa diagnosis is controversial. This study aimed to determine the relationship between hormonal patterns and PCa, and to find a cut-off point of hormone levels to assess PCa risk.A prospective analysis was undertaken of 279 patients referred for first or second prostate biopsy in the Hospital Clínic Barcelona from November 2006 to May 2009. The indication for prostate biopsy was suspicion of PCa based on the results of digital rectal examination (DRE) and/or elevation of serum prostate-specific antigen (PSA). Screening was carried out with a 5+5-core transrectal ultrasound-guided prostate biopsy. Age, prostate volume, DRE (normal or abnormal), biopsy findings (normal or report of PCa), PSA, free-to-total PSA, PSA density, testosterone and sex hormone-binding globulin (SHBG) were also prospectively recorded. Free and bioavailable testosterone were calculated using Vermeulen's formula.In the multivariate analysis, abnormal DRE [odds ratio (OR = 5.46, p < 0.001], SHBG levels ? 66.25 nmol/l [OR = 3.27; 95% confidence interval (CI) 1.52 to 7.04, p < 0.002] and bioavailable testosterone levels ? 104 ng/dl (OR = 4.92, 95% CI 1.78 to 13.59, p = 0.002) were related to the diagnosis of prostate adenocarcinoma. Age, free testosterone, PSA, testosterone, PSA/testosterone, PSA/free testosterone and PSA/bioavailable testosterone were not related to PCa diagnosis.Low bioavailable testosterone levels and high SHBG levels were related to a 4.9- and 3.2-fold risk of detection of PCa on prostate biopsy owing to PSA elevation or abnormal DRE. This fact may be useful in the clinical scenario in counselling patients at risk for PCa.

Keywords

AntigenBioavailable testosteroneClassification criteriaDiagnosisDiseaseHormonal patternInternational consensus statementProstate biopsyProstate cancerRiskShbgThrombosisUpdate

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Scandinavian Journal Of Urology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2013, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Urology. Notably, the journal is positioned en el Cuartil Q4 for the agency WoS (JCR) in the category Urology & Nephrology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-20, the following number of citations:

  • WoS: 13
  • Scopus: 22
  • Europe PMC: 11
  • OpenCitations: 21

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 28.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 28 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 8.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: England.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Alcaraz Asensio, Antonio).