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Analysis of institutional authors

Marcuello MAuthorDuran-Sanchon SAuthorCastells AAuthorGironella MCorresponding Author

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June 27, 2019
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Circulating biomarkers for early detection and clinical management of colorectal cancer

Publicated to: Molecular Aspects Of Medicine. 69 107-122 - 2019-10-01 69(), DOI: 10.1016/j.mam.2019.06.002

Authors: Marcuello, Maria; Vymetalkova, Veronika; Neves, Rui P L; Duran-Sanchon, Saray; Vedeld, Hege Marie; Tham, Emma; van Dalum, Guus; Fluegen, Georg; Garcia-Barberan, Vanesa; Fijneman, Remond Ja; Castells, Antoni; Vodicka, Pavel; Lind, Guro E; Stoecklein, Nikolas H; Heitzer, Ellen; Gironella, Meritxell

Affiliations

Cancer Registry of Norway Institute of Population-Based Cancer Research - Author
Charles Univ Prague, Czech Acad Sci, Inst Expt Med, Prague, Czech Republic - Author
Charles Univ Prague, Med Fac 1, Inst Biol & Med Genet, Prague, Czech Republic - Author
Charles University - Author
Christian Doppler Lab Liquid Biopsies Early Detec, Graz, Austria - Author
Heinrich Heine Univ Dusseldorf, Med Fac, Dusseldorf, Germany - Author
Heinrich Heine Univ Dusseldorf, Univ Hosp, Expt Surg Oncol Gen Visceral & Pediat Surg, Dusseldorf, Germany - Author
Hosp Clinico San Carlos, IdISSC, CIBERONC, Mol Oncol Lab, Madrid, Spain - Author
Hospital Clinico San Carlos de Madrid - Author
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden - Author
Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden - Author
Karolinska University Hospital - Author
Med Univ Graz, Diagnost & Res Ctr Mol BioMed, Inst Human Genet, Graz, Austria - Author
Medizinische Universitat Graz - Author
Netherlands Canc Inst, Dept Pathol, Amsterdam, Netherlands - Author
Oslo Univ Hosp, Norwegian Radium Hosp, Res KG Jebsen Colorectal Canc Res Ctr, Dept Mol Oncol,Inst Canc Res, Oslo, Norway - Author
The Netherlands Cancer Institute - Author
Uniklinik Dusseldorf - Author
Univ Barcelona, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Gastrointestinal & Pancreat Oncol Grp,Hosp Clin B, Barcelona, Spain - Author
Universitat de Barcelona - Author
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Abstract

© 2019 The Authors New non-invasive approaches that can complement and improve on current strategies for colorectal cancer (CRC) screening and management are urgently needed. A growing number of publications have documented that components of tumors, which are shed into the circulation, can be detected in the form of liquid biopsies and can be used to detect CRC at early stages, to predict response to certain therapies and to detect CRC recurrence in a minimally invasive way. The analysis of circulating tumor DNA (ctDNA), tumor-derived cells (CTC, circulating tumor cells) or circulating microRNA (miRNA) in blood and other body fluids, have a great potential to improve different aspects of CRC management. The challenge now is to find which types of components, biofluids and detection methods would be the most suitable to be applied in the different steps of CRC detection and treatment. This chapter will provide an up to date review on ctDNA, CTCs and circulating miRNAs as new biomarkers for CRC, either for clinical management or early detection, highlighting their advantages and limitations.

Keywords

cell-free dnacirculating tumor cells (ctc)diagnostic leukapheresisdroplet digital pcrfecal occult bloodliquid biopsiesliquid biopsymethylated sept9 dnamicrornaperipheral-bloodpotential biomarkersprognosisreverse transcription-pcrscreeningtumor-cellsCell-free dnaCirculating tumor cells (ctc)Diagnostic leukapheresisDroplet digital pcrFecal occult bloodLiquid biopsiesLiquid biopsyMethylated sept9 dnaMicrornaPeripheral-bloodPotential biomarkersPrognosisReverse transcription-pcrScreeningTumor-cells

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Molecular Aspects Of Medicine due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 7/139, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, Research & Experimental. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 8.53. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 7.53 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-12-15, the following number of citations:

  • WoS: 192
  • Scopus: 210
  • Europe PMC: 116

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-15:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 283.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 282 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).
  • The number of mentions on Wikipedia: 1 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Austria; Czech Republic; Germany; Netherlands; Norway; Sweden.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Marcuello Fernandez, Maria) and Last Author (Gironella Cos, Meritxell).

the author responsible for correspondence tasks has been Gironella Cos, Meritxell.