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Analysis of institutional authors

Mullol, JAuthorPujols, LAuthorAlobid, IAuthorPerez-Gonzalez, MAuthorFuentes, MAuthorCallejas, FdAuthorValero, AAuthorPicado, CAuthorRoca-Ferrer, JCorresponding Author

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May 5, 2014
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Fluticasone Furoate Inhibits Cytokine Secretion from Nasal Epithelial Cells and Reduces Eosinophil Survival in an in vitro Model of Eosinophilic Inflammation

Publicated to: International Archives Of Allergy And Immunology. 163 (3): 225-233 - 2014-01-01 163(3), DOI: 10.1159/000358489

Authors:

Mullol, Joaquim; Pujols, Laura; Alobid, Isam; Perez-Gonzalez, Maria; Fuentes, Mireya; Callejas, Francisco de Borja; Valero, Antonio; Picado, Cesar; Roca-Ferrer, Jordi
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Affiliations

Ctr Invest Biomed Red Enfermedades Resp CIBERES, Barcelona, Spain - Author
ENT Hosp Clin, Rhinol Unit, Barcelona, Spain - Author
ENT Hosp Clin, Smell Clin, Barcelona, Spain - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, CELLEX, ES-08036 Barcelona, Spain - Author
Univ Barcelona, Pneumol & Allergy Dept, Allergy Unit, Hosp Clin,Dept Med, Barcelona, Spain - Author
Universitat de Barcelona - Author
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Abstract

Fluticasone furoate (FF) is an intranasal corticosteroid indicated for the treatment of allergic rhinitis (AR). However, the anti-inflammatory effects of FF in the nasal mucosa have yet to be investigated thoroughly. The aim of this study was to investigate the effect of FF on eosinophil survival and cytokine secretion from nasal mucosa epithelial cells.Epithelial cells obtained from nasal mucosa were stimulated with 10% fetal bovine serum (FBS) in the presence of FF (from 10(-12) to 10(-7)M) for 6-24 h. Cytokine [granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-8] concentrations in supernatants were measured by ELISA. Peripheral blood eosinophils were incubated for 4 days with epithelial cell secretions in the presence or absence of FF (from 10(-12) to 10(-7)M) and survival was assessed by Trypan blue dye exclusion. Results are expressed as medians of the minimum effective concentration and IC values.FBS stimulated the secretion of GM-CSF, IL-6 and IL-8. FF significantly inhibited GM-CSF (up to 10(-10)M, IC25 = 12.6 pM), IL-6 (up to 10(-10)M, IC25 = 65.8 pM) and IL-8 (up to 10(-11)M, IC25 = 8.6 pM) secretion induced by FBS (n = 8). Epithelial cell secretions induced eosinophil survival from day 1 to day 4 (n = 6). This effect was significantly inhibited by FF (up to 10(-12)M) at day 3 (IC50 = 3.22 nM) and day 4 (IC50 = 1.29 nM).The results obtained in this in vitro model suggest that FF may reduce upper airway eosinophilic inflammation through decreasing cytokine secretion from epithelial cells and reducing eosinophil survival.© 2014 S. Karger AG, Basel.
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Keywords

AdultAgedAndrostadienesAnti-allergic agentsCell survivalCells, culturedCytokinesEnzyme-linked immunosorbent assayEosinophilsEpithelial cellsFemaleFluticasone furoateGranulocyte-macrophage colony-stimulating factorHumansInflammationInterleukinsMaleMiddle agedNasal mucosa

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Archives Of Allergy And Immunology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-29:

  • WoS: 6
  • Scopus: 5
  • Europe PMC: 5
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-29:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 22.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 22 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.
  • The number of mentions on the social network X (formerly Twitter): 6 (Altmetric).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Switzerland.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Mullol i Miret, Joaquim) and Last Author (Roca Ferrer, Jordi).

the author responsible for correspondence tasks has been Roca Ferrer, Jordi.

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