{rfName}
Di

Indexed in

License and use

Altmetrics

Analysis of institutional authors

Bargallo Alabart, NuriaAuthorPadilla, NCorresponding AuthorJunque, CAuthorFigueras, FAuthorSanz-Cortes, MAuthorArranz, AAuthorDonaire, AAuthorFigueras, JAuthorGratacos, EAuthor
Share
Publications
>
Article

Differential vulnerability of gray matter and white matter to intrauterine growth restriction in preterm infants at 12 months corrected age

Publicated to:Brain Research. 1545 (1545): 1-11 - 2014-01-30 1545(1545), DOI: 10.1016/j.brainres.2013.12.007

Authors: Padilla, Nelly; Junque, Carme; Figueras, Francesc; Sanz-Cortes, Magdalena; Bargllo, Nuria; Arranz, Angela; Donaire, Antonio; Figueras, Josep; Gratacos, Eduard

Affiliations

Corp Sanitaria Clin, Ctr Invest Biomed Enfermedades Raras CIBERER, Barcelona 08036, Spain - Author
Inst Dinuest Biomed August Pi i Sunyer IDIBAPS, Barcelona 08036, Spain - Author
Univ Barcelona, Dept Maternal Fetal Med, ICGON, Hosp Clin, E-08028 Barcelona, Spain - Author
Univ Barcelona, Dept Neonatol, ICGON, Hosp Clin, E-08028 Barcelona, Spain - Author
Univ Barcelona, Dept Neurol, Inst Neurosci, Hosp Clin, E-08028 Barcelona, Spain - Author
Univ Barcelona, Dept Psychiat & Clin Psychobiol, Fac Med, E-08028 Barcelona, Spain - Author
Univ Barcelona, Dept Radiol, Ctr Diagnost Imatge CDIC, Hosp Clin, E-08028 Barcelona, Spain - Author
Universitat de Barcelona - Author
See more

Abstract

Intrauterine growth restriction (IUGR) is associated with a high risk of abnormal neurodevelopment. Underlying neuroanatomical substrates are partially documented. We hypothesized that at 12 months preterm infants would evidence specific white-matter microstructure alterations and gray-matter differences induced by severe IUGR. Twenty preterm infants with IUGR (26-34 weeks of gestation) were compared with 20 term-born infants and 20 appropriate for gestational age preterm infants of similar gestational age. Preterm groups showed no evidence of brain abnormalities. At 12 months, infants were scanned sleeping naturally. Gray-matter volumes were studied with voxel-based morphometry. White-matter microstructure was examined using tract-based spatial statistics. The relationship between diffusivity indices in white matter, gray matter volumes, and perinatal data was also investigated. Gray-matter decrements attributable to IUGR comprised amygdala, basal ganglia, thalamus and insula bilaterally, left occipital and parietal lobes, and right perirolandic area. Gray-matter volumes positively correlated with birth weight exclusively. Preterm infants had reduced FA in the corpus callosum, and increased FA in the anterior corona radiata. Additionally, IUGR infants had increased FA in the forceps minor, internal and external capsules, uncinate and fronto-occipital white matter tracts. Increased axial diffusivity was observed in several white matter tracts. Fractional anisotropy positively correlated with birth weight and gestational age at birth. These data suggest that IUGR differentially affects gray and white matter development preferentially affecting gray matter. At 12 months IUGR is associated with a specific set of structural gray-matter decrements. White matter follows an unusual developmental pattern, and is apparently affected by IUGR and prematurity combined. Copyright © 2013 Elsevier B.V. All rights reserved.

Keywords
adadolescentsagaanisotropyappropriate for gestational ageaxial diffusivitybrain developmentcachildrencorrected agedarteldiffeomorphic anatomical registration through exponentiated lie algebradiffusiondiffusion tensor imagingdtifafamily-wise errorfractional anisotropyfwegmgray mattergray matter developmentintrauterine growth restrictioniugrmagnetic resonance imagingmaturationmdmean diffusivitymriprematurityradial diffusivityrdsgasmall for gestational agetbsstract-based spatial statisticsvbmvoxel-based morphometrywhite matter developmentwmAdAdolescentsAgaAge factorsAnisotropyAppropriate for gestational ageAxial diffusivityBirthBornBrainBrain developmentCaCellsChildrenCorrected ageDartelDiffeomorphic anatomical registration through exponentiated lie algebraDiffusionDiffusion tensor imagingDtiFaFamily-wise errorFemaleFetal growth retardationFractional anisotropyFweGene-expressionGestational ageGmGray matterGray matter developmentHumansInfant, newbornInfant, prematureInfant, premature, diseasesIntestineIntrauterine growth restrictionIugrMagnetic resonance imagingMaleMaturationMdMean diffusivityMriNerve fibers, myelinatedPrematurityRadial diffusivityRatRdSgaSmall for gestational ageTbssTract-based spatial statisticsVbmVoxel-based morphometryWhite matterWhite matter developmentWm

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Brain Research due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurology (Clinical).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.92. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.22 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 18.05 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-14, the following number of citations:

  • WoS: 83
  • Scopus: 91
  • Europe PMC: 60
  • OpenCitations: 88
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-14:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 139.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 139 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Amsterdam.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Padilla Gomes, Nelly Fabiola) and Last Author (Gratacós Solsona, Eduard).

the author responsible for correspondence tasks has been Padilla Gomes, Nelly Fabiola.