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Analysis of institutional authors

Ramirez Flores, SaraAuthorPerez-Del-Pulgar, SCorresponding AuthorCrespo, GAuthorCoto-Llerena, MAuthorMensa, LAuthorGarcia-Valdecasas, JcAuthorNavasa, MAuthorForns, XAuthor

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May 13, 2014
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Characterization of the cross-neutralizing antibody response against hepatitis C virus in the liver transplantation setting

Publicated to:American Journal Of Transplantation. 11 (4): 767-774 - 2011-04-01 11(4), DOI: 10.1111/j.1600-6143.2011.03440.x

Authors: Dragun, J; Perez-Del-Pulgar, S; Crespo, G; Ramirez, S; Coto-Llerena, M; Mensa, L; Garcia-Valdecasas, J C; Navasa, M; Forns, X

Affiliations

Hosp Clin Barcelona, Liver Surg & Liver Transplantat Unit, CIBERehd, IDIBAPS, Barcelona, Spain - Author
Hosp Clin Barcelona, Liver Unit, CIBERehd, IDIBAPS, Barcelona, Spain - Author
Univ Barcelona, Barcelona, Spain - Author
Universitat de Barcelona - Author

Abstract

Neutralizing antibody (nAb) activity during the course of natural infection is believed to be crucial to combating virus propagation. The aim of this study was to measure the impact of nAb response on HCV early kinetics and genetic evolution in the liver transplantation (LT) setting. A cohort of 28 patients undergoing LT for HCV-related cirrhosis was included in the study. Viral load, nAb titers and hypervariable region 1 (HVR1) sequences were determined in serum samples obtained before and at different time points after LT. Serum nAb titers were assessed using HCV pseudoparticles (HCVpp). HVR1 sequences were obtained by direct sequencing. Patients were classified according to viral kinetic patterns (plateau or increasing), during the first week after LT. All patients demonstrated high titers of nAbs before LT, although this was not associated with early kinetic patterns or HVR1 evolution during the first week after LT. We found that in patients with plateau HCV early kinetics, the virus required adaptive mutations, while in those with increasing viral loads, the HVR1 region remained largely conserved (p = 0.015). These data suggest that HCV adaptation via selection of the best-fitted variants may account for early viral kinetics following LT.©2011 The Authors Journal compilation©2011 The American Society of Transplantation and the American Society of Transplant Surgeons.

Keywords

AdolescentAdultAgedAntibodies, neutralizingAntibody formationBloodCross reactionsEvolutionFemaleHepacivirusHepatitis cHepatitis c antibodiesHepatitis c virusHuman-immunodeficiency-virusHumansIn-vitroInfectionLiver transplantationMaleMiddle agedNeutralizationPreventionRecurrenceRna, viralSequence evolutionTransplantation, homologousViral loadVirus kineticsYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal American Journal Of Transplantation due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2011, it was in position 2/199, thus managing to position itself as a Q1 (Primer Cuartil), in the category Surgery.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-02:

  • WoS: 9
  • Scopus: 9
  • Europe PMC: 8

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 21 (PlumX).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Forns Bernhardt, Xavier).

the author responsible for correspondence tasks has been Pérez Del Pulgar Gallart, Sofía.