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Analysis of institutional authors

Sanchez-Tillo, EAuthorLazaro, AAuthorCuatrecasas, MAuthorVaquero, EcAuthorCastells, AAuthorEngel, PAuthorPostigo, ACorresponding Author

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May 13, 2014
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ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1

Publicated to: ONCOGENE. 29 (24): 3490-3500 - 2010-06-17 29(24), DOI: 10.1038/onc.2010.102

Authors:

Sanchez-Tillo, E; Lazaro, A; Torrent, R; Cuatrecasas, M; Vaquero, E C; Castells, A; Engel, P; Postigo, A
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Affiliations

Hosp Clin Barcelona, Dept Pathol, Barcelona, Spain - Author
Hospital Clinic Barcelona - Author
ICREA, Barcelona, Spain - Author
IDIBAPS, CIBEREHD, Hosp Clin, Dept Gastroenterol, Barcelona 08036, Spain - Author
IDIBAPS, Dept Hematol & Oncol, Grp Transcript Regulat, Barcelona 08036, Spain - Author
Institució Catalana de Recerca i Estudis Avançats - Author
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS - Author
Univ Barcelona, Sch Med, Dept Cellular Biol & Pathol, Immunol Unit, Barcelona, Spain - Author
Univ Pompeu Fabra, Master Program Biotechnol, Barcelona, Spain - Author
Universitat de Barcelona - Author
Universitat Pompeu Fabra - Author
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Abstract

Loss of E-cadherin is a key initial step in the transdifferentiation of epithelial cells to a mesenchymal phenotype, which occurs when tumor epithelial cells invade into surrounding tissues. Expression of the nuclear factor ZEB1 induces an epithelial-to-mesenchymal transition and confers a metastatic phenotype on carcinomas by repressing the E-cadherin gene at the transcriptional level. In this study, we show that ZEB1 interacts with the SWI/SNF chromatin-remodeling protein BRG1 to regulate E-cadherin independently of CtBP, its traditional co-repressor. Blocking the interaction between ZEB1 and BRG1 induces expression of E-cadherin and downregulation of the mesenchymal marker vimentin. ZEB1 and BRG1 colocalize in E-cadherin-negative cells from cancer lines and in the stroma of normal colon. Colocalization of ZEB1 and BRG1 in epithelial cells is only found in those de-differentiated cells characterized by nuclear beta-catenin staining at the invasive edge of the tumor. Our results identify ZEB1/BRG1 as a new transcriptional mechanism regulating E-cadherin expression and epithelial-to-mesenchymal transdifferentiation that may be involved during the initial stages of tumor invasion.
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Keywords

Brg1CadherinsCell dedifferentiationCell line, tumorColonColonic neoplasmsColorectal-cancerCytologyDna helicasesE-cadherinEpithelial cellsEpithelial-mesenchymal transition (emt)Gene expression regulation, neoplasticGene-expressionHomeodomain proteinsHumansImpactMesodermMetabolismNeoplasm invasivenessNuclear proteinsOrgan specificityPromoter regions, geneticProtein transportRisk factorsSmarca4 protein, humanSurgical-treatmentSurvivalTranscription factorsTranscription, geneticZeb1Zeb1 protein, humanZinc finger e-box-binding homeobox 1

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal ONCOGENE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2010, it was in position 30/177, thus managing to position itself as a Q1 (Primer Cuartil), in the category Cell Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • Google Scholar: 588
  • WoS: 397
  • Scopus: 289
  • Europe PMC: 391
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 382.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 382 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: England.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Sánchez Tilló, Ester) and Last Author (Postigo, Antonio).

the author responsible for correspondence tasks has been Postigo, Antonio.

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