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Grant support

This work was sponsored by the Instituto de Salud Carlos III (ISCIII) through the Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2017-2020/ISCIII-FEDER project reference number PI17/00199, the Carmen Delgado/Miguel Perez-Mateo AESPANC-ACANPAN 2016 grant, and the Generalitat de Catalunya (2017-SGR-225) to P.N.

Analysis of institutional authors

Martinez-Bosch, NAuthorVisa, LAuthorNavarro, PCorresponding Author

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Review

The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer

Publicated to:Cells. 9 (3): E689- - 2020-03-01 9(3), DOI: 10.3390/cells9030689

Authors: Manero-Rupérez, N; Martínez-Bosch, N; Navarro, P; Barranco, LE; Visa, L

Affiliations

Abstract

Galectins are a family of proteins that bind beta-galactose residues through a highly conserved carbohydrate recognition domain. They regulate several important biological functions, including cell proliferation, adhesion, migration, and invasion, and play critical roles during embryonic development and cell differentiation. In adults, different galectin members are expressed depending on the tissue type and can be altered during pathological processes. Numerous reports have shown the involvement of galectins in diseases, mostly inflammation and cancer. Here, we review the state-of-the-art of the role that different galectin family members play in pancreatic cancer. This tumor is predicted to become the second leading cause of cancer-related deaths in the next decade as there is still no effective treatment nor accurate diagnosis for it. We also discuss the possible translation of recent results about galectin expression and functions in pancreatic cancer into clinical interventions (i.e., diagnosis, prediction of prognosis and/or therapy) for this fatal disease.

Keywords

galectinsimmunosuppressionpancreatic cancerActivationApoptosisDuctal adenocarcinomaExpressionGalectinGalectinsHumanHumansImmunosuppressionImmunosuppression therapyImmunosuppressive treatmentImmunotherapyIn-vitroMetabolismMolecular targeted therapyMolecularly targeted therapyPancreas tumorPancreatic cancerPancreatic neoplasmsProceduresProliferationStellate cellsStromaT-cellsTissueTumor-metastasis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cells due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.58, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 3.84 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-09, the following number of citations:

  • WoS: 26
  • Scopus: 27
  • Europe PMC: 20
  • OpenCitations: 21

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 58.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 58 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.5.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Navarro Medrano, Pilar).

the author responsible for correspondence tasks has been Navarro Medrano, Pilar.