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Analysis of institutional authors

Pascal, MAuthorMunoz-Cano, RAuthorPalacin, AAuthorVilella, RAuthorPicado, CAuthorJuan, MAuthorSanchez-Lopez, JAuthorRueda, MAuthorValero, AAuthorYague, JAuthorBartra, JCorresponding Author
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Article

Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens

Publicated to:Clinical And Experimental Allergy. 42 (10): 1529-1539 - 2012-10-01 42(10), DOI: 10.1111/j.1365-2222.2012.04071.x

Authors: Pascal, M; Munoz-Cano, R; Reina, Z; Palacin, A; Vilella, R; Picado, C; Juan, M; Sanchez-Lopez, J; Rueda, M; Salcedo, G; Valero, A; Yaguee, J; Bartra, J

Affiliations

Centro de Biotecnologia y Genomica de Plantas, Universidad Politecnica de Madrid - Author
Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias - Author
Ctr Biotecnol & Genom Plantas UPM INIA, Madrid, Spain - Author
Ctr Invest Red Enfermedades Resp CIBERES, Barcelona, Spain - Author
Hosp Clin Barcelona, CDB, Serv Immunol, Barcelona 08036, Spain - Author
Hospital Clinic Barcelona - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain - Author
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS - Author
Univ Barcelona, Hosp Clin, Serv Pneumol, Unitat Allergia, Barcelona, Spain - Author
Universitat de Barcelona - Author
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Abstract

Multiple plant-food sensitizations with a complex pattern of clinical manifestations are a common feature of lipid transfer protein (LTP)-allergic patients. Component-resolved diagnosis permits the diagnosis of the allergen sensitization profile.We sought to clinically characterize and describe the plant-food and pollen molecular sensitization profile in patients with LTP syndrome.Forty-five subjects were recruited, after being diagnosed with multiple plant-food allergies sensitized to LTP, but not to any other plant-food allergen, according to the molecular allergen panel tested (Pru p 3 (LTP), Pru p 1 (Bet v 1-like), Pru p 4 (profilin) and those included in a commercial microarray of 103 allergenic components). IgE-mediated food-allergy symptoms and pollinosis were collected. Patients were skin prick tested with a plant-food and pollens panel, and specific IgE to Tri a 14 was evaluated.A heterogeneous group of plant-foods was involved in local and systemic symptoms: oral allergy syndrome (75.6%), urticaria (66.7%), gastrointestinal disorders (55.6%) and anaphylaxis (75.6%), 32.4% of which were cofactor dependent (Non-Steroidal Anti-inflammatory Drugs, exercise). All tested subjects were positive to peach and Pru p 3, Tri a 14 and to some of the LTPs included in the microarray. Pollinosis was diagnosed in 75.6% of subjects, with a broad spectrum of pollen and pollen-allergen sensitization. Plane tree and mugwort were the statistically significant pollens associated with Pru p 3.Several plant-foods, taxonomically unrelated, independent of peach involvement, are implicated in LTP syndrome. Local symptoms should be evaluated as a risk marker for anaphylaxis because they are frequently associated with cofactor-dependent anaphylaxis. The association of these symptoms with pollinosis, especially plane tree pollinosis, could be part of this syndrome in our area.© 2012 Blackwell Publishing Ltd.

Keywords
adultsanaphylaxisartemisia pollencofactorscomponent-resolved diagnosisdiagnosisfeaturesfruitshypersensitivityltp syndromepeach allergypollenprevalenceAdolescentAdultAllergensAnaphylaxisAntigens, plantAsthmaBody-mass indexCarrier proteinsClinical characterizationCofactorsComponent-resolved diagnosisCross-reactivityDiagnosisEstrogen replacement therapyFat distributionFeaturesFemaleFood hypersensitivityGrowth-factor-iHumansHypersensitivityImmunoglobulin eLipid transfer proteins, plantLtp syndromeMaleMetabolic syndromeMiddle agedMidlife womenPlacebo-controlled trialPlant proteinsPlantsPollenPrevalenceQuality-of-lifeRhinitis, allergic, seasonalSkin testsSyndromeYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical And Experimental Allergy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 4/23, thus managing to position itself as a Q1 (Primer Cuartil), in the category Allergy.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 4.3. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.6 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 32.75 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-22, the following number of citations:

  • WoS: 166
  • Scopus: 188
  • Europe PMC: 43
  • OpenCitations: 156
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 136.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 136 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.85.
  • The number of mentions on the social network X (formerly Twitter): 11 (Altmetric).
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: HOBOKEN.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Pascal Capdevila, Mariona) and Last Author (Bartra Tomàs, Joan).

the author responsible for correspondence tasks has been Bartra Tomàs, Joan.