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Grant support

This work was supported by the National Institute of General Medical Sciences grant GM065519 to SJL, and a FRAXA Research Foundation fellowship to MB. Two-photon microscopy of acute hippocampal slices was performed in the lab of Prof. Mark F. Bear at MIT. We thank Alexandria D. Liang, Ellen Minnihan, and Joey Cotruvo for assistance with stopped flow experiments, and Dr Robert J. Radford for insightful discussions.

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Bosch, MiquelAuthor

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Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc

Publicated to:Metallomics. 5 (6): 648-655 - 2013-01-01 5(6), DOI: 10.1039/c3mt00103b

Authors: Huang, Zhen; Zhang, Xiao-an; Bosch, Miquel; Smith, Sarah J.; Lippard, Stephen J.;

Affiliations

MIT, Dept Chem, Cambridge, MA 02139 USA - Author
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA - Author

Abstract

We report the characterization of tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable zinc chelator for intercepting biological mobile zinc. Compared to N,N,N',N'-tetrakis(2-pyridylmethyl) ethylenediamine (TPEN), TPA chelates zinc with faster kinetics in cuvettes, live cells, and brain slices. TPA also is generally less toxic than TPEN in cell culture. Mechanistic analysis indicates that these improvements arise from both the electronic and steric properties of TPA including weaker metal-binding affinity, lower pK(a), and smaller size. These results demonstrate that TPA chelation is a valuable addition to the methodologies available for investigating mobile zinc in biology.

Keywords

ApoptosisBinding ligandsComplex-formationCopperDynamic-rangeFluorescent sensorsLong-term potentiationProstate-cancerTpenZn2+

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Metallomics due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2013, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Metals and Alloys. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.04, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-23, the following number of citations:

  • WoS: 28
  • Scopus: 44
  • OpenCitations: 40

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-23:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 53.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 53 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.25.
  • The number of mentions on the social network Facebook: 1 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.