Indexed in

License and use

Citations

Cited 66 times in

Cited 72 times in

Cited 56 times in

Altmetrics

Grant support

We thank all the authors of the included studies, especially those who kindly shared their data for inclusion in this meta-analysis. Funding for this study was provided by Instituto de Salud Carlos III (ISCIII) (PI16/00889, PI16/00144 and PI14/00292), FEDER funds/European Regional Development Fund (ERDF) -a way to build Europe-, a PERIS award from the Ministry of Health of the Gerteralitat de Catalunya (SLT006/17/249), and AGAUR (2017 SGR 1247). CIBERSAM is an initiative of the Carlos III Health Institute. MP-P and MA -N are supported by a FI Grant from AGAUR-Generalitat de Catalunya (2015 FI_B 00839 and 2017 FI_B 00327, respectively), grants co-ftmded by the European Social Fund (ESF) ESF, Investing in your future. JR and CS -M are supported by a 'Miguel Servet' contract from the ISCIII (CP14/00041 and CPII16/00048, respectively). AA-E is supported by a PFIS Predoctoral Contract (FI16/00311). BV is supported by a KU Leuven start-up grant STG/17/035. BJH is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (1124472).

Analysis of institutional authors

Share

Common and distinct neural correlates of fear extinction and cognitive reappraisal: A meta-analysis of fMRI studies

Publicated to:Neuroscience And Biobehavioral Reviews. 104 102-115 - 2019-09-01 104(), DOI: 10.1016/j.neubiorev.2019.06.029

Authors: Pico-Perez, M; Alemany-Navarro, M; Dunsmoor, J E; Radua, J; Albajes-Eizagirre, A; Vervliet, B; Cardoner, N; Benet, O; Harrison, B J; Soriano-Mas, C; Fullana, M A

Affiliations

Abstract

Cognitive reappraisal and fear extinction learning represent two different approaches to emotion regulation. While their respective neural correlates have been widely studied with functional magnetic resonance imaging (fMRI), few direct comparisons between these processes have been conducted. We conducted a meta-analysis of fMRI studies of reappraisal and fear extinction, with the aim of examining both commonalities and differences in their neural correlates. We also conducted independent analyses that focused on specific reappraisal strategies (reinterpretation, distancing). Overall, we observed that the dorsal anterior cingulate cortex (dACC) and the bilateral anterior insular cortex (AIC) were similarly consistently engaged by reappraisal and extinction. Extinction was more consistently linked to activation of sensory and emotion processing regions, whereas reappraisal was more consistently associated with activation of a dorsal fronto-parietal network. Interestingly, the amygdala was preferentially deactivated by distancing. These results suggest that the dACC and the AIC are involved in domain-general regulatory networks. Differences between extinction and reappraisal could be explained by their relative processing demands on visual perceptual versus higher cognitive neural systems.Copyright © 2019 Elsevier Ltd. All rights reserved.

Keywords