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Analysis of institutional authors

Llinas, LAuthorLazaro, AAuthorEngel, PCorresponding Author

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June 23, 2014
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New B-cell CD molecules

Publicated to: Immunology Letters. 134 (2): 104-112 - 2011-01-01 134(2), DOI: 10.1016/j.imlet.2010.09.019

Authors:

Matesanz-Isabel, Jessica; Sintes, Jordi; Llinas, Laia; de Salort, Jose; Lazaro, Adriana; Engel, Pablo
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Affiliations

Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Dept Cell Biol Immunol & Neurosci, Immunol Unit,Sch Med, E-08036 Barcelona, Spain - Author
Universitat de Barcelona - Author

Abstract

B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has been instrumental to the discovery and functional characterization of human B-cell populations. Moreover, many events regulating B-cell development, activation, and effector functions are orchestrated by these cell-surface molecules. During the Ninth HLDA Workshop (HLDA9) eighteen new CDs were allocated to cell-surface molecules expressed on B cells: CD210a (IL10RA), CD215 (IL15RA), CD270 (TNFRSF14), CD307a (FCRL1), CD307b (FCRL2), CD307c (FCRL3), CD307d (FCRL4), CD351 (FCAMR), CD352 (SLAMF6), CD353 (SLAMF8), CD354 (TREM1), CD355 (CRTAM), CD357 (TNFRSF18), CD358 (TNFRSF21), CD360 (IL21RA), CD361 (EVI2B), CD362 (SDC2), and CD363 (S1PR1). Here we present their expression patterns on leukocytes, including T lymphocytes, NK cells, granulocytes, monocytes, plasmacytoid and monocyte-derived dendritic cells, and several B-cell subsets. These new CD molecules are expressed on B cells at various stages of differentiation; from bone marrow precursor pro-B cells to plasma cells. Three of them, CD307a, CD307b and CD307d, exhibit a B-cell restricted expression pattern, whereas the rest are also present on other leukocytes. In this paper we also review the structural characteristics, expression, and function of these new CD molecules. The availability of monoclonal antibodies directed against novel B cell-surface molecules will have broad implications not only for B-cell biology, but also for the development of new diagnostic and therapeutic tools.Copyright © 2010 Elsevier B.V. All rights reserved.
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Keywords

AnimalsAntibodies, monoclonalB cellsBone marrow cellsCell-surface receptorsCytologyFacsHlda9HumansMiceMonoclonal antibodies

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal IMMUNOLOGY LETTERS due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2011, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Immunology and Allergy. Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Immunology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-01:

  • WoS: 50
  • Scopus: 53
  • Europe PMC: 1
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 139.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 139 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.
  • The number of mentions on Wikipedia: 3 (Altmetric).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Netherlands.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Engel Rocamora, Pablo).

the author responsible for correspondence tasks has been Engel Rocamora, Pablo.

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