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Analysis of institutional authors

Riga, MaurizioCorresponding AuthorCelada PAuthorArtigas FCorresponding Author

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August 19, 2020
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Sub-chronic vortioxetine (but not escitalopram) normalizes brain rhythm alterations and memory deficits induced by serotonin depletion in rats

Publicated to:Neuropharmacology. 178 108238- - 2020-11-01 178(), DOI: 10.1016/j.neuropharm.2020.108238

Authors: Riga, Maurizio S; Sanchez, Connie; Celada, Pau; Artigas, Francesc

Affiliations

Aarhus Univ, Translat Neuropsychiat Unit, Clin Med, Skovagervej 2, DK-28240 Risskov, Denmark - Author
CSIC, Dept Neuroquim & Neurofarmacol, Inst Invest Biomed Barcelona, Barcelona, Spain - Author
H Lundbeck & Co AS, Ottiliavej 9, DK-2500 Valby, Denmark - Author
Inst Invest Biomed August Pi & Sunyer IDIBAP, Barcelona, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain - Author
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Abstract

Major depressive disorder (MDD) is a chronic and disabling psychiatric disorder characterized by a wide range of signs/symptoms, including cognitive dysfunction. Vortioxetine (VOR) is a multimodal antidepressant drug with pro-cognitive actions in animal models and MDD patients. The VOR-mediated blockade of 5-HT3-R in a subpopulation of GABA interneurons enhances pyramidal neuron activity in rat medial prefrontal cortex, an effect possibly underlying its pro-cognitive action. Brain oscillations are involved in regulation of cognitive function. We therefore examined VOR effects on oscillatory activity in four brain areas of freely-moving rats (prelimbic cortex, PrL; nucleus accumbens, NAc; dorsal hippocampus, dHPC; paraventricular thalamic nucleus, PVA), in standard and in serotonin-depleted rats showing recognition memory deficits. 4-chloro-dl-phenylalanine (pCPA) markedly reduced low frequency oscillations (LFO, mainly 1 Hz oscillations) and enhanced theta oscillations in PrL and NAc. It also reduced gamma and high frequency oscillations (HFO) in PVA. Subchronic VOR and escitalopram (ESC) treatments had little effect on oscillatory activity in standard rats. However, VOR -but not ESC- prevented recognition memory deficits in 5-HT-depleted rats, and normalized LFO and theta powers in PrL and NAc. In parallel, VOR -but not ESC- prevented the deficit in PrL-dHPC gamma coherence, but not the decrease in gamma and HFO powers in PVA. Overall, this supports a prominent role of serotonergic neurotransmission on brain oscillatory activity, particularly in cortico-striatal pathways linked to short-term recognition memory. Further, VOR prevented pCPA-induced cognitive deficits by normalizing oscillatory activity at lower frequencies in the PrL-NAc pathway, also normalizing the PrL-dHPC coherence at gamma frequencies.Copyright © 2020 Elsevier Ltd. All rights reserved.

Keywords

5-ht receptors 35-ht(3) receptors5-hydroxytryptamine (serotonin)AnimalsAntidepressive agents, second-generationBrainBrain oscillationsCircadian rhythmCitalopramEscitalopramFenclonineMaleMemory disordersRatsRats, wistarSerotoninSerotonin 5-ht3 receptor antagonistsSerotonin antagonistsShort-term memoryVortioxetine

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Neuropharmacology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 54/276, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-17, the following number of citations:

  • WoS: 11
  • Scopus: 10
  • Europe PMC: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-17:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 39 (PlumX).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Denmark.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Riga MS) and Last Author (Artigas Perez, Francesc).

the authors responsible for correspondence tasks have been Riga, Maurizio, Riga MS and Artigas Perez, Francesc.