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Analysis of institutional authors

Muñoz Santos , CarlosAuthorMunoz Garcia, Carmen MariaAuthorNavarro Ponz, AlfonsAuthorMartínez-Rodenas FAuthorCanals JAuthorDiaz TAuthorMunoz CAuthorBiete AAuthorMonzo MAuthorNavarro ACorresponding Author

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September 18, 2020
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Article

LincRNA-p21 Levels Relates to Survival and Post-Operative Radiotherapy Benefit in Rectal Cancer Patients

Publicated to: Life. 10 (9): E172-12 - 2020-09-01 10(9), DOI: 10.3390/life10090172

Authors:

Li, Y; Castellano, JJ; Moreno, I; Martínez-Rodenas, F; Hernandez, R; Canals, J; Diaz, T; Han, B; Muñoz, C; Biete, A; Monzo, M; Navarro, A
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Affiliations

Hosp Municipal Badalona, Dept Med Oncol & Surg, Badalona 08911, Spain - Author
HOSPITAL MUNICIPAL DE BADALONA - Author
Univ Barcelona, Fac Med & Hlth Sci, Human Anat Unit, Mol Oncol & Embryol Lab,IDIBAPS, Barcelona 08036, Spain - Author
Univ Barcelona, Hosp Clin Barcelona, Radiat Oncol Dept, Barcelona 08036, Spain - Author
Universitat de Barcelona - Author
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Abstract

LincRNA-p21 is a long non-coding RNA involved in the p53 pathway and angiogenesis regulation that acts as prognostic marker in several tumors. In the present study, we aimed to analyze the clinical value of lincRNA-p21 in 177 resected stage I-III colorectal cancer (CRC) patients. Tumor and normal paired tissue and plasma samples from tumor-draining mesenteric veins and paired peripheral veins were analyzed. LincRNA-p21 expression was determined by RTqPCR and correlated with disease-free (DFS) and overall survival (OS). LincRNA-p21 was downregulated in tumor versus normal tissue (p = 0.0012). CRC patients with high lincRNA-p21 expression had shorter DFS (p = 0.0372) and shorter OS (p = 0.0465). Of note, the major prognostic impact was observed in the subset of rectal cancer patients where patients with high lincRNA-p21 levels had worse DFS (p = 0.0226) and OS (p = 0.0457). Interestingly, rectal cancer patients with high lincRNA-p21 benefited from post-operative chemoradiotherapy, as indicated by a longer OS in the group of high lincRNA-p21 patients receiving post-operative chemoradiotherapy (p = 0.04). Finally, patients with high lincRNA-p21 levels in mesenteric vein (MV) had shorter OS (p = 0.0329). LincRNA-p21 is a marker of advanced disease and worse outcome in CRC. Moreover, rectal cancer patients with high lincRNA-p21 levels could benefit from post-operative chemoradiotherapy, and plasmatic-lincRNA-p21 is a promising liquid biopsy biomarker.
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Keywords

Colorectal cancerLincrna-p21Liquid biopsyLong non-coding rnaRadiochemotherapyRectal cancer

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Life due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Paleontology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-02:

  • WoS: 8
  • Scopus: 7
  • Europe PMC: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 10 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Li Y) and Last Author (Navarro López, Alba).

the author responsible for correspondence tasks has been Navarro López, Alba.

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