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Analysis of institutional authors

Barrio PCorresponding AuthorGual, AAuthorTeixidor LAuthor
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Phosphatidylethanol for Monitoring Alcohol Use in Liver Transplant Candidates: An Observational Study

Publicated to:Journal Of Clinical Medicine. 9 (9): E3060-9 - 2020-09-01 9(9), DOI: 10.3390/jcm9093060

Authors: Barrio, Pablo; Gual, Antoni; Lligona, Anna; Teixidor, Lidia; Weinmann, Wolfgang; Yegles, Michel; Wurst, Friedrich M

Affiliations

Lab Natl Sante, Serv Toxicol, L-3555 Dudelange, Luxembourg - Author
Psychiat Univ Hosp, CH-4002 Basel, Switzerland - Author
Univ Barcelona, Grp Recerca Addic Clin GRAC GRE, Hosp Clin & Univ Barcelona, Dept Psychiat,Clin Inst Neurosci,IDIBAPS,RTA RETI, Villarroel,170, Barcelona 08036, Spain - Author
Univ Bern, Inst Forens Med, CH-3012 Bern, Switzerland - Author

Abstract

Liver transplantation remains an essential procedure for many patients suffering from alcoholic liver disease. Alcohol use monitoring remains paramount all through the stages of this complex process. Direct alcohol biomarkers, with improved specificity and sensibility, should replace traditional indirect markers. Phosphatidylethanol (PEth) has been recently tested in alcoholic liver disease patients, but more evidence is needed, especially in comparison with other direct biomarkers. We conducted an observational study among patients awaiting liver transplantation. We analyzed Peth in blood, ethylglucuronide (EtG) in hair and urine and ethylsulphate (EtS) in urine, using mass spectrometry methods. In addition, transaminases, and self-reports were analyzed. A total of 50 patients were included (84% men, mean age 59 years (SD = 6)). 18 patients (36%) screened positive for any marker. Self-reports were positive in 3 patients. EtS was the biomarker with more positive screens. It also was the most frequently exclusive biomarker, screening positive in 7 patients who were negative for all other biomarkers. PEth was positive in 5 patients, being the only positive biomarker in 2 patients. It showed a false negative in a patient admitting alcohol use the previous week and screening positive for EtG and EtS. Hair EtG was positive in 3 patients who had negative Peth, EtG. EtG did not provide any exclusive positive result.A combination of biomarkers seems to be the best option to fully ascertain abstinence in this population. Our study suggest EtS might also play a significant role.

Keywords
alcohol dependenceconsumptiondependencediseasedisordersdrinkingethanolethylglucuronidephosphatidylethanolself-reportsubstance usevalidationAdultAlanine aminotransferaseAlcohol consumptionAlcohol dependenceAlcohol liver diseaseAlcohol use disorders identification testAlcoholismAminotransferaseArticleAspartate aminotransferaseBiological markerBlood analysisClinical articleCross-sectional studyEthyl glucuronideEthylglucuronideEthylsulphateFemaleGamma glutamyltransferaseHair analysisHumanLimit of quantitationLiver transplantationLiver transplatationMaleMass spectrometryObservational studyPhosphatidylethanolSelf reportSpainUnclassified drugUrinalysisUrinary ethyl glucuronide

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Clinical Medicine due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 39/167, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, General & Internal.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.52, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-07, the following number of citations:

  • WoS: 11
  • Scopus: 11
  • Europe PMC: 4
  • OpenCitations: 12
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-07:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Luxembourg; Switzerland.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Barrio Giménez, Pablo) .

the author responsible for correspondence tasks has been Barrio Giménez, Pablo.