{rfName}
Co

Indexed in

License and Use

Icono OpenAccess

Citations

26

Altmetrics

Analysis of institutional authors

Angelats, EdgarAuthor

Share

November 3, 2020
Publications
>
Article
Sí

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors

Publicated to: Molecular Neurobiology. 56 (2): 1196-1210 - 2019-01-01 56(2), DOI: 10.1007/s12035-018-1140-7

Authors:

Aguinaga, David; Medrano, Mireia; Cordomi, Arnau; Jimenez-Roses, Mireia; Angelats, Edgar; Casanovas, Mireia; Vega-Quiroga, Ignacio; Canela, Enric I.; Petrovic, Milos; Gysling, Katia; Pardo, Leonardo; Franco, Rafael; Navarro, Gemma;
[+]

Affiliations

‎ Inst Salud Carlos III, Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain - Author
‎ Pontificia Univ Catolica Chile, Dept Cellular & Mol Biol, Fac Biol Sci, Santiago, Chile - Author
‎ Univ Autonoma Barcelona, Lab Med Computac, Unitat Bioestadist, Fac Med, Bellaterra 08193, Spain - Author
‎ Univ Barcelona, Dept Biochem & Physiol, Fac Pharm, Barcelona, Spain - Author
‎ Univ Barcelona, Sch Biol, Dept Biochem & Mol Biomed, Barcelona, Spain - Author
‎ Univ Barcelona, Sch Biol, Diagonal 643, Barcelona 08028, Spain - Author
‎ Univ Cent Lancashire, Sch Pharm & Biomed Sci, Preston PR1 2HE, Lancs, England - Author
See more

Abstract

Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (sigma R-1) mediates cocaine anorectic effects by interacting in neurons with growth/hormone/secretagogue (ghrelin) receptors. Cocaine increases colocalization of sigma R-1 and GHS-R1a at the cell surface. Moreover, in transfected HEK-293T and neuroblastoma SH-SY5Y cells, and in primary neuronal cultures, pretreatment with cocaine or a sigma R-1 agonist inhibited ghrelin-mediated signaling, in a similar manner as the GHS-R1a antagonist YIL-781. Results were similar in G protein-dependent (cAMP accumulation and calcium release) and in partly dependent or independent (ERK1/2 phosphorylation and label-free) assays. We provide solid evidence for direct interaction between receptors and the functional consequences, as well as a reliable structural model of the macromolecular sigma R-1-GHS-R1a complex, which arises as a key piece in the puzzle of the events linking cocaine consumption and appetitive/consummatory behaviors.
[+]

Keywords

cross-regulationdrug addictionfunctional selectivityg protein-coupled heteroreceptor complexneuroendocrineAttenuateBrain-sigmaCross-regulationCrystal-structureDrug addictionFunctional selectivityG protein-coupled heteroreceptor complexInduced toxicityInvolvementLigandsNeuroendocrineNeuropeptide-yOpioid analgesiaPeptide-yyProteinReceptor heteromer

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal MOLECULAR NEUROBIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 65/272, thus managing to position itself as a Q1 (Primer Cuartil), in the category Neurosciences.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • WoS: 9
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 57.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 57 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).
  • The number of mentions on Wikipedia: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
[+]

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Chile; United Kingdom.

[+]

Awards linked to the item

This work was supported by grants from the Spanish Ministry of Innovation and Competitiveness (MINECO Ref. No. BFU2015-664405-R, SAF2015-74627-JIN and SAF2016-77830-R; they may include FEDER European Union funds).
[+]