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The PREDIMED-Plus trial was supported by the Spanish government's official funding agency for biomedical research, ISCIII, through the Fondo de Investigacion para la Salud (FIS) and co-funded by European Union ERDF/ESF, A way to make Europe/Investing in your future (five coordinated FIS projects led by JS-S and JVid, including the following project PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560 and PI19/01332), the Special Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant to JS-S, the European Research Council (Advanced Research Grant 2013-2018, 340918) to MAM-G, the Recercaixa Grant to JS-S (2013ACUP00194), grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016 and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, and funds from the European Regional Development Fund (CB06/03). This research was also partially funded by EU-H2020 Grant (EAT2BENICE/H2020-SFS-2016-2; Ref 728018). Study resulting from the SLT006/17/00246 grant was funded by the Department of Health of the Generalitat de Catalunya by the call Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut. We thank CERCA Programme/Generalitat de Catalunya for institutional support. This work is partially supported by ICREA under the ICREA Academia program. IP-G receives a grant from the Spanish Ministry of Education, Culture and Sports (FPU 17/01925). L.C.-B. is the recipient of a predoctoral fellowship from the Generalitat de Catalunya's Department of Universities (FI-DGR 2017). NB-T is supported by a postdoctoral fellowship (Juan de la Cierva-Formacion, FJC2018-036016-I) MRBL was supported by Miguel Servet Type I program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER.

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Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population

Publicated to:European Journal Of Nutrition. 60 (5): 2381-2396 - 2021-08-01 60(5), DOI: 10.1007/s00394-020-02415-w

Authors: Paz-Graniel, Indira; Babio, Nancy; Becerra-Tomas, Nerea; Toledo, Estefania; Camacho-Barcia, Lucia; Corella, Dolores; Castaner-Nino, Olga; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, J Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J; Fernandez-Aranda, Fernando; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Garcia-Rios, Antonio; Bueno-Cavanillas, Aurora; Gaforio, Jose J; Matia-Martin, Pilar; Daimiel, Lidia; Sanchez, Vicente Martin; Vidal, Josep; Prieto-Sanchez, Lucia; Ros, Emilio; Razquin, Cristina; Mestres, Cristina; Sorli, Jose V; Cuenca-Royo, Aida M; Rios, Angel; Torres-Collado, Laura; Vaquero-Luna, Jessica; Perez-Farinos, Napoleon; Zulet, M Angeles; Sanchez-Villegas, Almudena; Casas, Rosa; Bernal-Lopez, M Rosa; Santos-Lozano, Jose Manuel; Corbella, Xavier; Mateos, David; Buil-Cosiales, Pilar; Jimenez-Murcia, Susana; Fernandez-Carrion, Rebeca; Forcano-Gamazo, Laura; Lopez, Meritxell; Sempere-Pascual, Miguel Angel; Moreno-Rodriguez, Anai; Gea, Alfredo; De la Torre-Fornell, Rafael; Salas-Salvado, Jordi

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Abstract

Coffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS).PREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n?=?6427; mean age?=?65?±?5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment.Total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44-0.90 and OR 0.56; 95% CI 0.38-0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47-0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A).Coffee consumption and total dietary caffeine intake were associated with better cognitive functioning as measured by various neuropsychological tests in a Mediterranean cohort of elderly individuals with MetS.ISRCTN89898870. Registration date: July 24, 2014.

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