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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Llaó-Cid LAuthorChapaprieta VAuthorColomer DAuthorMartin-Subero JiAuthor

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March 22, 2021
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Article

EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia

Publicated to: Leukemia. 35 (11): 3152-3162 - 2021-11-01 35(11), DOI: 10.1038/s41375-021-01198-1

Authors:

Llaó-Cid, L; Roessner, PM; Chapaprieta, V; Öztürk, S; Roider, T; Bordas, M; Izcue, A; Colomer, D; Dietrich, S; Stilgenbauer, S; Hanna, B; Martín-Subero, JI; Seiffert, M
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Affiliations

‎ Ctr Invest Biomed Red Canc CIBERONC, Barcelona, Spain - Author
‎ German Canc Res Ctr, Mol Genet, Heidelberg, Germany - Author
‎ Heidelberg Univ, Dept Med Hematol Oncol & Rheumatol 5, Heidelberg, Germany - Author
‎ Heidelberg Univ, Fac Biosci, Heidelberg, Germany - Author
‎ Hosp Clin Barcelona, Hematopathol Sect, Barcelona, Spain - Author
‎ Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain - Author
‎ Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain - Author
‎ Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany - Author
‎ Saarland Univ, Dept Internal Med 1, Homburg, Germany - Author
‎ Univ Barcelona, Dept Fonaments Clin, Barcelona, Spain - Author
‎ Univ Freiburg, Freiburg, Germany - Author
‎ Univ Hosp RWTH Aachen, Inst Mol Med, Aachen, Germany - Author
‎ Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Germany - Author
‎ Univ Ulm, Dept Internal Med 3, Ulm, Germany - Author
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Abstract

Genome-wide association studies identified a single-nucleotide polymorphism (SNP) affecting the transcription factor Eomesodermin (EOMES) associated with a significantly increased risk to develop chronic lymphocytic leukemia (CLL). Epigenetic analyses, RNA sequencing, and flow cytometry revealed that EOMES is not expressed in CLL cells, but in CD8+ T cells for which EOMES is a known master regulator. We thus hypothesized that the increased CLL risk associated with the EOMES SNP might be explained by its negative impact on CD8+ T-cell-mediated immune control of CLL. Flow cytometry analyses revealed a higher EOMES expression in CD8+ T cells of CLL patients compared to healthy individuals, and an accumulation of PD-1+ EOMES+ CD8+ T cells in lymph nodes rather than blood or bone marrow in CLL. This was in line with an observed expansion of EOMES+ CD8+ T cells in the spleen of leukemic Eµ-TCL1 mice. As EOMES expression was highest in CD8+ T cells that express inhibitory receptors, an involvement of EOMES in T-cell exhaustion and dysfunction seems likely. Interestingly, Eomes-deficiency in CD8+ T cells resulted in their impaired expansion associated with decreased CLL control in mice. Overall, these observations suggest that EOMES is essential for CD8+ T-cell expansion and/or maintenance, and therefore involved in adaptive immune control of CLL.
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Keywords

AnimalsCase-control studiesCd8-positive t-lymphocytesEomes protein, humanEomes protein, mouseFemaleGenome-wide association studyGood health and well-beingLeukemia, lymphocytic, chronic, b-cellLymph nodesMaleMiceMice, inbred c57blMice, knockoutT-box domain proteins

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal LEUKEMIA due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 7/78, thus managing to position itself as a Q1 (Primer Cuartil), in the category Hematology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.38. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.44 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-05, the following number of citations:

  • WoS: 35
  • Scopus: 27
  • Europe PMC: 17
  • Open Alex: 33
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 80.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 80 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Good Health And Well-being, with a probability of 80% according to the mBERT algorithm developed by Aurora University.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Llaó Cid, Laura) .

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Awards linked to the item

Open Access funding enabled and organized by Projekt DEAL.
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