{rfName}

Indexed in

License and use

Icono OpenAccess

Citations

26

Altmetrics

Analysis of institutional authors

Maduell, FranciscoCorresponding AuthorBroseta, Jose JesusAuthorRodriguez-Espinosa, DianaCorresponding AuthorCuadrado-Payan, ElenaAuthorRodas, Lida MariaAuthorGomez, MiquelAuthorArias-Guillen, MartaAuthorVera, MCorresponding Author

Share

June 29, 2021
Publications
>
Article
Sí

Efficacy and safety of the Clearum dialyzer

Publicated to:Artificial Organs. 45 (10): 1195-1201 - 2021-10-01 45(10), DOI: 10.1111/aor.13993

Authors: Maduell, F; Broseta, JJ; Rodríguez-Espinosa, D; Hermida-Lama, E; Cuadrado-Payán, E; Rodas, LM; Gómez, M; Arias-Guillén, M; Fontseré, N; Vera, M; Rico, N

Affiliations

Hosp Clin Barcelona, Dept Biochem, Barcelona, Spain - Author
Hosp Clin Barcelona, Dept Nephrol, Barcelona, Spain - Author
Univ Barcelona, Dept Med, Barcelona, Spain - Author

Abstract

The Clearum dialyzer, built by Medtronic, became commercially available in several European countries in 2020, but there are still no reports of in vivo data. The aim of this study was to evaluate the efficacy and risk of hypoalbuminemia of this dialyzer compared with previously evaluated hemodialysis (HD), expanded hemodialysis (HDx), and postdilution hemodiafiltration (HDF) treatments. A prospective study was carried out in 15 patients. Each patient underwent seven dialysis sessions: FX80 Cordiax in HD, Clearum HS17 in HD, Phylther 17-SD in HDx, Theranova 400 in HDx, Phylther 17-G in postdilution HDF, Clearum HS17 in postdilution HDF, and FX80 Cordiax in postdilution HDF. The reduction ratios of urea, creatinine, ss(2)-microglobulin, myoglobin, prolactin, alpha(1)-microglobulin, alpha(1)-acid glycoprotein, and albumin were compared intraindividually. Dialysate albumin loss was also measured. Comparison of dialysis techniques revealed no differences between small molecules, but HDx and HDF were significantly higher than HD with medium and large molecular weights. The Clearum dialyzer in HDF obtained similar results to FX80 Cordiax in HDF, was slightly superior to Phylther 17-G in HDF, and was statistically superior to both dialyzers in HDx. Albumin losses with the Clearum dialyzer were among the lowest, both in HD and HDF treatments. The highest global removal score (GRS) values were obtained with the helixone and Clearum dialyzers in HDF, with similar results both in HD and HDF. In addition, the GRS values with HDx treatments were statistically significantly higher than those with HD. The new Clearum dialyzer has excellent behavior and tolerance in HD and HDF. Its adequate permeability has been proven with its maximal performance in HDF, which could represent an upgrade versus its predecessor polyphenylene dialyzers.

Keywords

dialyzer performanceexpanded hemodialysishelixonehemodiafiltrationhemodialysispolyethersulfonepolyphenyleneDialyzer performanceExpanded hemodialysisHelixoneHemodiafiltrationHemodialysisPolyethersulfonePolyphenylene

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Artificial Organs, and although the journal is classified in the quartile Q3 (Agencia WoS (JCR)), its regional focus and specialization in Transplantation, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.09. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-05, the following number of citations:

  • WoS: 21

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 20.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Maduell Canals, Francisco) .

the authors responsible for correspondence tasks have been Maduell Canals, Francisco, Rodriguez Espinoza, Diana María and Vera Rivera, Manel.