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This work was supported by Miguel Servet Research Contract MS14/00041 and Research Project PI14/00292 from the Plan Nacional de I+D +i 2013-2016, the Instituto de Salud Carlos III-Subdireccion General de Evaluacion y Fomento de la Investigacion, the European Regional Development Fund (FEDER), and by PFIS Predoctoral Contract FI16/00311. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Analysis of institutional authors

Fullana Llinàs, María NeusAuthorAlbajes-Eizagirre, ACorresponding AuthorSolanes, AAuthorFullana, MaAuthorTorrent, CAuthorSole, BAuthorBonnin, CmAuthorVieta, EAuthorRadua, JCorresponding Author
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Article

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Publicated to:Jove-Journal Of Visualized Experiments. 2019 (153): e59841- - 2019-11-01 2019(153), DOI: 10.3791/59841

Authors: Albajes-Eizagirre, Anton; Solanes, Aleix; Angel Fullana, Miquel; Ioannidis, John P A; Fusar-Poli, Paolo; Torrent, Carla; Sole, Brisa; Mar Bonnin, Caterina; Vieta, Eduard; Mataix-Cols, David; Radua, Joaquim

Affiliations

Hosp Clin Barcelona, Inst Neurosci, Barcelona, Spain - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain - Author
Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res & Educ, Stockholm, Sweden - Author
Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England - Author
Mental Hlth Res Networking Ctr CIBERSAM, Barcelona, Spain - Author
South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England - Author
Stanford Univ, Sch Humanities & Sci, Dept Stat, Stanford, CA 94305 USA - Author
Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA 94305 USA - Author
Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA - Author
Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA - Author
Univ Barcelona, Barcelona, Spain - Author
Univ Pavia, Dept Nervous Syst & Behav Sci, Pavia, Italy - Author
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Abstract

Most methods for conducting meta-analysis of voxel-based neuroimaging studies do not assess whether effects are not null, but whether there is a convergence of peaks of statistical significance, and reduce the assessment of the evidence to a binary classification exclusively based on p-values (i.e., voxels can only be statistically significant or non-statistically significant). Here, we detail how to conduct a meta-analysis using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI), a novel method that uses a standard permutation test to assess whether effects are not null. We also show how to grade the strength of the evidence according to a set of criteria that considers a range of statistical significance levels (from more liberal to more conservative), the amount of data or the detection of potential biases (e.g., small-study effect and excess of significance). To exemplify the procedure, we detail the conduction of a meta-analysis of voxel-based morphometry studies in obsessive-compulsive disorder, and we provide all the data already extracted from the manuscripts to allow the reader to replicate the meta-analysis easily. SDM-PSI can also be used for meta-analyses of functional magnetic resonance imaging, diffusion tensor imaging, position emission tomography and surface-based morphometry studies.

Keywords
familywise error ratefunctional magnetic resonance imaging (fmri)issue 153meta-analysisneuroimagingpermutation of subject images (psi)seed-based d mapping (sdm)threshold-free cluster enhancement (tfce)voxel-based morphometry (vbm)BrainBrain mappingDiffusion tensor imagingFamilywise error rateFunctional magnetic resonance imaging (fmri)HumansImage processing, computer-assistedInferenceIssue 153Magnetic resonance imagingMeta-analysisNeuroimagingNeuroscienceObsessive-compulsive disorderPermutation of subject images (psi)Seed-based d mapping (sdm)Threshold-free cluster enhancement (tfce)Voxel-based morphometry (vbm)

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Jove-Journal Of Visualized Experiments due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Chemical Engineering (Miscellaneous). Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Multidisciplinary Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.3. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.14 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 12.41 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-09, the following number of citations:

  • WoS: 81
  • Scopus: 96
  • Europe PMC: 40
  • OpenCitations: 41
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 92.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 92 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy; Sweden; United Kingdom; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Albajes Eizagirre, Anton) and Last Author (Raduà Castaño, Joaquim).

the authors responsible for correspondence tasks have been Albajes Eizagirre, Anton and Raduà Castaño, Joaquim.