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Paredes PCorresponding AuthorCarreras-Diéguez NAuthorNinerola-Baizan AAuthorGaba LAuthorPahisa JAuthorDel Pino MAuthorDiaz-Feijoo BAuthorFuster DAuthorPerissinotti AAuthorRomero IAuthorFernández-Galán EAuthorTorne AAuthor

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September 30, 2021
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Evaluation of patients with advanced epithelial ovarian cancer before primary treatment: correlation between tumour burden assessed by [18F]FDG PET/CT volumetric parameters and tumour markers HE4 and CA125

Publicated to:European Radiology. 32 (4): 2200-2208 - 2022-04-01 32(4), DOI: 10.1007/s00330-021-08305-x

Authors: Glickman, A; Carreras-Diéguez, N; Pahisa, J; Fusté, P; Del Pino, M; Díaz-Feijóo, B; González-Bosquet, E; Agustí, N; Torné, A; Paredes, P; Niñerola-Baizán, A; Sánchez-Izquierdo, N; Fuster, D; Perissinotti, A; Romero, I; Gaba, L; Fernández-Galán, E; Carrasco, JL; Gil-Ibáñez, B

Affiliations

12 Octubre Univ Hosp, Dept Obstet & Gynecol, Gynecol Oncol & Minimally Invas Gynecol Surg Unit, Madrid, Spain - Author
Biomed Res Networking Ctr Bioengn Biomat & Nanome, Barcelona, Spain - Author
Hosp Clin Barcelona, Biomed Diagnost Ctr, Dept Biochem & Mol Genet, Barcelona, Spain - Author
Hosp Clin Barcelona, Dept Med Oncol, Barcelona, Spain - Author
Hosp Clin Barcelona, Dept Nucl Med, Barcelona, Spain - Author
Hosp Clin Barcelona, Inst Clin Ginecol Obstet & Neonatol, Gynaecol Oncol Unit, Barcelona, Spain - Author
Hospital Clinic Barcelona - Author
Hospital Clinic Barcelona , Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS - Author
Hospital Universitario 12 de octubre - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain - Author
Univ Barcelona, Dept Basic Clin Practice, Biostat, Barcelona, Spain - Author
Univ Barcelona, Fac Med, Barcelona, Spain - Author
Universitat de Barcelona - Author
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Abstract

Accurate assessment of disease extent is required to select the best primary treatment for advanced epithelial ovarian cancer patients. Estimation of tumour burden is challenging and it is usually performed by means of a surgical procedure. Imaging techniques and tumour markers can help to estimate tumour burden non-invasively. 2-[18F]FDG PET/CT allows the evaluation of the whole-body disease. This study aimed to correlate HE4 and CA125 serum concentrations with tumour burden evaluated by volumetric 2-[18F]FDG PET/CT parameters in advanced high-grade epithelial ovarian cancer.We included 66 patients who underwent 2-[18F]FDG PET/CT and serum tumour markers determination before primary treatment. Volumes of interest were delimited in every pathological uptake. Whole-body metabolic tumour volume (wb_MTV) and total lesion glycolysis (wb_TLG) were calculated summing up every VOI's MTV value. SUVmax thresholds were set at 40% (MTV40 and TLG40) and 50% (MTV50 and TLG50). In addition, four VOI subgroups were defined: peritoneal carcinomatosis, retroperitoneal nodes, supradiaphragmatic nodes, and distant metastases. MTV and TLG were calculated for each group by adding up the corresponding MTV values. TLG was calculated likewise.wb_MTV and wb_TLG were found to be significantly correlated with serum CA125 and HE4 concentrations. The strongest correlation was observed between HE4 and wb_MTV40 (r?=?0.62, p?

Keywords

ca-125 antigenf-18-fdg pet/ctguidelineshuman epididymis protein 4neoadjuvant chemotherapypositron emission tomographypredictsprognosissurvivaltumour biomarkerstumour burdenBiomarkers, tumorCarcinoma, ovarian epithelialEmission tomography/computed tomographyFluorodeoxyglucose f18Human epididymis protein 4HumansOvarian epithelial carcinomaOvarian neoplasmsPositron emission tomographyPositron emission tomography computed tomographyPrognosisRadiopharmaceuticalsRetrospective studiesTumor burdenTumour biomarkers, ca-125 antigenTumour burden

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal European Radiology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 16/135, thus managing to position itself as a Q1 (Primer Cuartil), in the category Radiology, Nuclear Medicine & Medical Imaging.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.29. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 3.55 (source consulted: Dimensions Sep 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-09-07, the following number of citations:

  • WoS: 9
  • Scopus: 6
  • Europe PMC: 8

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-09-07:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 23 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.9.
  • The number of mentions on the social network X (formerly Twitter): 9 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Torné Bladé, Aureli).

the author responsible for correspondence tasks has been Paredes Barranco, Pilar.