{rfName}
Le

Indexed in

License and Use

Icono OpenAccess

Citations

146

Altmetrics

Analysis of institutional authors

Centeno MAuthor

Share

November 17, 2021
Publications
>
Article
Sí

Levetiracetam reduces abnormal network activations in temporal lobe epilepsy

Publicated to: Neurology. 83 (17): 1508-1512 - 2014-10-21 83(17), DOI: 10.1212/wnl.0000000000000910

Authors:

Wandschneider B, Stretton J, Sidhu M, Centeno M, Kozák LR, Symms M, Thompson PJ, Duncan JS, Koepp MJ
[+]

Affiliations

Great Ormond St Hosp Sick Children, Imaging & Biophys Dept, UCL Inst Child Hlth, London WC1N 3JH, England - Author
Semmelweis Univ, MR Res Ctr, H-1085 Budapest, Hungary - Author
UCL Inst Neurol, Dept Clin & Expt Epilepsy, London, England - Author
Univ Cambridge, MRC, Cognit & Brain Sci Unit, Cambridge CB2 1TN, England - Author
See more

Abstract

We used functional MRI (fMRI) and a left-lateralizing verbal and a right-lateralizing visual-spatial working memory (WM) paradigm to investigate the effects of levetiracetam (LEV) on cognitive network activations in patients with drug-resistant temporal lobe epilepsy (TLE).In a retrospective study, we compared task-related fMRI activations and deactivations in 53 patients with left and 54 patients with right TLE treated with (59) or without (48) LEV. In patients on LEV, activation patterns were correlated with the daily LEV dose.We isolated task- and syndrome-specific effects. Patients on LEV showed normalization of functional network deactivations in the right temporal lobe in right TLE during the right-lateralizing visual-spatial task and in the left temporal lobe in left TLE during the verbal task. In a post hoc analysis, a significant dose-dependent effect was demonstrated in right TLE during the visual-spatial WM task: the lower the LEV dose, the greater the abnormal right hippocampal activation. At a less stringent threshold (p < 0.05, uncorrected for multiple comparisons), a similar dose effect was observed in left TLE during the verbal task: both hippocampi were more abnormally activated in patients with lower doses, but more prominently on the left.Our findings suggest that LEV is associated with restoration of normal activation patterns. Longitudinal studies are necessary to establish whether the neural patterns translate to drug response.This study provides Class III evidence that in patients with drug-resistant TLE, levetiracetam has a dose-dependent facilitation of deactivation of mesial temporal structures.© 2014 American Academy of Neurology.
[+]

Keywords

cognitionWorking-memory

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NEUROLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position 8/192, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.27. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-04, the following number of citations:

  • WoS: 44
  • Europe PMC: 33
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 99.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 99 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 14.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
[+]

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Hungary; United Kingdom.

[+]

Awards linked to the item

Funded by the Wellcome Trust (project grant 083148). The Wolfson Trust and the Epilepsy Society supported the Epilepsy Society MRI scanner. This work was undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR UCLH/UCL Biomedical Research Centre funding scheme. B. Wandschneider was funded by a fellowship of the German Research Foundation (Deutsche Forschungsgemeinschaft; WA 3135/1-1). M. Centeno was supported by Fundacion Caja Madrid. L. R. K. was supported by the Bolyai Research Fellowship Program of the Hungarian Academy of Sciences.
[+]