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Grant support

This study was supported by Becas de Investigacion de la FEHH (Fundacion Espanola de Hematologia y Hemoterapia) to PM, the PI19/00925 grant (Instituto de Salud Carlos III) to LM, and the PI19/00887 grant (Instituto de Salud Carlos III) to ALG and EG.

Analysis of institutional authors

Mozas PCorresponding AuthorRivero AAuthorRivas-Delgado AAuthorCorrea JgAuthorNadeu FAuthorGine EAuthorDelgado JAuthorVillamor NAuthorCampo EAuthorMagnano LAuthorLópez-Guillermo AAuthor

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December 13, 2021
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First external validation of the FLIPI-L score in a single-centre series of patients with follicular lymphoma

Publicated to:Hematological Oncology. 40 (2): 297-301 - 2022-04-01 40(2), DOI: 10.1002/hon.2953

Authors: Mozas, Pablo; Rivero, Andrea; Rivas-Delgado, Alfredo; Correa, Juan Gonzalo; Condom, Maria; Nadeu, Ferran; Gine, Eva; Delgado, Julio; Villamor, Neus; Campo, Elias; Magnano, Laura; Lopez-Guillermo, Armando

Affiliations

Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain - Author
Hosp Clin Barcelona, Dept Haematol, Villarroel 170, Barcelona 08036, Spain - Author
Hosp Clin Barcelona, Dept Pathol, Hematopathol Unit, Barcelona, Spain - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain - Author
Univ Barcelona, Barcelona, Spain - Author
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Abstract

The FLIPI-L has recently been proposed as a novel prognostic index in follicular lymphoma (FL), combining FLIPI and the presence of lymphopenia. In our single-center validation in 381 FL patients, lymphopenia was less frequent than in the original publication and thus the distribution of risk categories was different. Although it was not able to properly predict time to first treatment, FLIPI-L performed slightly better than FLIPI alone in the prediction of response, early relapse, progression-free and overall survival, and histological transformation. This new tool or others encompassing parameters from the microenvironment might improve upon the prognostic ability of classical scores.

Keywords

follicular lymphomaprognostic scorerelapserisksurvivaltransformationFlipi-lFollicular lymphomaHumansLymphoma, follicularNeoplasm recurrence, localPrognosisPrognostic scoreRisk factorsRituximabSurvivalTumor microenvironment

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Hematological Oncology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 3.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 3 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Mozas Fernández, Pablo) and Last Author (López Guillermo, Armando).

the author responsible for correspondence tasks has been Mozas Fernández, Pablo.