{rfName}

Indexed in

APC

4 000,00 Dollars

License and Use

Icono OpenAccess

Citations

2

Altmetrics

Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Tort-Merino ACorresponding AuthorFernandez-Villullas GCorresponding AuthorJuncà-Parella JCorresponding AuthorBosch BCorresponding AuthorLlado ACorresponding AuthorSanchez-Valle RCorresponding AuthorBalasa MCorresponding Author

Share

January 5, 2022
Publications
>
Meeting Abstract
Sí

ALTOIDA-iADL for the diagnosis of Mild Cognitive Impairment and early Alzheimer's disease

Publicated to: Alzheimers & Dementia. 17 Suppl 12 (S12): e057982-e057982 - 2021-01-01 17 Suppl 12(S12), DOI: 10.1002/alz.057982

Authors:

Tort-Merino A, Tarnanas I, Bügler M, Harms R, Fernandez-Villullas G, Juncà-Parella J, Bosch B, Lladó A, Sanchez-Valle R, Balasa M
[+]

Affiliations

Altoida Inc., Houston, TX, USA. - Author
Alzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, IDIBAPS, Barcelona, Spain. - Author

Abstract

Diagnostic accuracy for the early detection of mild cognitive impairment (MCI) is critical both in the clinical and research settings. Our aim was to evaluate the diagnostic performance of the ALTOIDA-iADL test in subjects with non-degenerative MCI and prodromal (pAD) and mild (mAD) Alzheimer's disease.ALTOIDA-iADL is a 10-minute administrable cognitive test, which assesses activities of daily living in the form of an augmented virtual reality game. The task consists of placing and finding virtual objects in a real environment and provides a final score (the NeuroMotor Index; NMI). The NMI is obtained by weighting multi-modal information such as hands' micromovements, walking bouts and speed, reaction time and navigation trajectory (among others), and represents the overall outcome of the individual task performance. Fifty-one participants were included and classified according to cerebrospinal fluid (CSF) AD biomarkers: MCI (n = 22; age: 68.2; MMSE: 26.5), pAD (n = 15; age: 69.4; MMSE: 24.0) and mAD (n = 14; age: 70.6; MMSE: 20.7).The NMI allowed differentiating between subjects with absence (Aβ-) and presence (Aβ+) of abnormalities in the amyloid biomarker (p < 0.01). Also, differences were found between the MCI group and the pAD (p < 0.01) and mAD (p < 0.01) groups (Fig. 1). ROC curves showed good diagnostic accuracy of the NMI in the discrimination between the Aβ- and Aβ+ (AUC = 0.777; p < 0.01), MCI and pAD (AUC = 0.781; p < 0.01) and MCI and mAD (AUC = 0.772; p < 0.01). The NMI did not discriminate between the pAD and mAD (AUC = 0.557; p = 0.61) groups (Fig. 2). The NMI correlated with CSF NfL levels (r = -.456; p < 0.05) and the MMSE score (r = .432; p < 0.01), showing an association with the degree of cognitive impairment.ALTOIDA-iADL is useful in the differential diagnosis between patients with non-degenerative MCI and prodromal and mild Alzheimer's disease. Its performance is related to the degree of impairment in cognitive screening tests and with biomarkers of axonal damage/neurodegeneration.© 2021 the Alzheimer's Association.
[+]

Keywords

Reduced inequalities

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Alzheimers & Dementia due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 4/212, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-06:

  • Open Alex: 2
  • Scopus: 2
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 11.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 10 - Reduce inequality within and among countries, with a probability of 61% according to the mBERT algorithm developed by Aurora University.
[+]

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Tort Merino, Adrià) and Last Author (Balasa, Mircea).

the authors responsible for correspondence tasks have been Tort Merino, Adrià, Fernández Villullas, Guadalupe, Juncà Parella, Jordi, Bosch Capdevila, Beatriz, Lladó Plarrumaní, Albert, Sanchez del Valle Díaz, Raquel and Balasa, Mircea.

[+]