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This work was supported by the National Natural Science Foundation of China (No. 82173252, No. 81871866) ; the Shaanxi Social Development Science and Technology Key Project (No. 2016SF-308) ; and the Project of Tangdu Hospital, the Fourth Military Medical University (2018 Key Talents) .

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Article

The DNA damage repair-related gene PKMYT1 is a potential biomarker in various malignancies

Publicated to:Translational Lung Cancer Research. 10 (12): 4600-4616 - 2021-12-17 10(12), DOI: 10.21037/tlcr-21-973

Authors: Shao, Changjian; Wang, Yuanyong; Pan, Minghong; Guo, Kai; Molnar, Tamas F; Kocher, Florian; Seeber, Andreas; Barr, Martin P; Navarro, Alfons; Han, Jing; Ma, Zhiqiang; Yan, Xiaolong

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Abstract

Background: Protein kinase membrane associated tyrosine/threonine 1 (PKMYT1) regulates cell cycle and is a part of DNA damage repair (DDR)-related signaling. Recent studies have identified a role for PKMYT1 in tumor immunity and DDR. Thus, we initiated this study aiming to characterize the molecular and immunological portrait of PKMYT1 in cancer. Methods: Transcriptomic data extrapolated from Genotype-Tissue Expression (GTEx), The Cancer Genome Atlas (TCGA), and Cancer Cell Line Encyclopedia (CCLE) datasets were used to determine the mRNA expression levels of PKMYT1. PKMYT1 mRNA expression status was correlated with patients’ prognosis as well as immune neoantigens, and immune checkpoints in 34 different tumors. The Tumor Immune Estimation Resource (TIMER) dataset was used to analyze immune infiltrating scores. Results: PKMYT1 mRNA is differentially expressed in common tumors and high expression levels of PKMYT1 mRNA is associated with poor prognosis except for malignant thymoma (THYM). In addition, PKMYT1 mRNA expression was correlated with tumor-infiltrating immune cells particularly in lung squamous cell carcinoma, esophageal carcinoma, THYM, and lung adenocarcinoma. An upregulation of immune checkpoints and neoantigens was observed in tumors with a high PKMYT1 mRNA expression. Data from gene set enrichment analysis (GSEA) revealed that PKMYT1 is involved in tumor immunogenicity, metabolism, and cell cycle progression. Conclusions: PKMYT1 is differentially expressed in various cancers and exerts an important effect on tumor immunity and progression. The PKMYT1 gene holds the potential as a new potential biomarker. Therefore, further studies are clearly needed to elaborate our findings. © Translational Lung Cancer Research. All rights reserved.

Keywords

activationbarriercarcinomacell lung-cancerchemotherapydna damage repair (ddr)immunitypan-cancer analysisprogressionproliferationsurvivalthreonine 1 (pkmyt1)tumorsAntigenArticleBiological markerCancer growthCd276 antigenCd28 antigenCd4+ t lymphocyteCd40 ligandCd70 antigenCd8+ t lymphocyteCell cycle progressionCell cycle proteinCell cycle protein 20Cell division cycle 25 aCell division cycle 25 bCell division cycle 25 cCell infiltrationCell proliferationChemokineChemokine receptorCyclin a1Cyclin a2Cyclin b1Cyclin b2Cyclin dependent kinase 1Differential gene expressionDisease free survivalDisease specific survivalDna damageDna damage repair (ddr)Dna repairEndothelin b receptorGene ontologyGlucocorticoid induced tumor necrosis factor receptorHumanImmune checkpoint inhibitorImmune responseImmunityImmunocompetent cellImmunogenicityImmunostimulating agentImmunosuppressive treatmentLymphocyte activation gene 3Lymphocyte antigenMalignant neoplasmMicrosatellite instabilityMrna expression levelNegative regulatory functionNeoantigenNucleic acid binding proteinOverall survivalPan-cancer analysisPolo like kinase 1Progression free survivalProtein expressionProtein kinase membrane associated tyrosineProtein kinase membrane associated tyrosine threonine 1Protein kinase membrane associated tyrosine/threonine 1 (pkmyt1)Rna sequencingSignal transductionToll like receptor 4Transcriptome sequencingTumor immune estimation resourceTumor immunityTumor immunogenicityTumor microenvironmentUnclassified drugUpregulationVasculotropin b

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Translational Lung Cancer Research due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 24/66, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Respiratory System. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Oncology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.52, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-05, the following number of citations:

  • WoS: 6
  • Scopus: 7
  • Europe PMC: 4
  • OpenCitations: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 17.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 17 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Austria; China; Hungary; United Kingdom.