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This work was funded by Projects PI16/01650 and PI20/00974 to JP, from the Spanish Ministry of Health and Consumer Affairs and FEDER. ANH was supported by the National Institutes of Health (NIH) K12 HD043483 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. This work was also supported by the American Cancer Society (#IRG-19-139-59) to ANH.

Analysis of institutional authors

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April 5, 2022
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Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain

Publicated to:Bmj Open. 11 (12): e055409- - 2021-12-01 11(12), DOI: 10.1136/bmjopen-2021-055409

Authors: Perea, Jose; Marti, Marc; Espin, Eloy; Hernandez-Villafranca, Sergio; Orihuela, Pilar; Tocino, Rosario Vidal; Alcazar, Jose Antonio; Vivas, Alfredo; Narvaez, Cristina; Prieto, Isabel; Asensio, Luis; Rojo, Irene Lopez; Garcia, Sara Encinas; Hurtado, Elena; Jimenez, Luis M; Jimenez, Fernando; Cavero, Adriana; Alvaro, Edurne; Fuenmayor, Maria Luisa; Toscano, Marta Jimenez; Comas, Mar Iglesias; Balaguer, Francesc; Daca, Maria; Ballestero, Araceli; Trill, Javier Die; Sanz, Gonzalo; Lopez, Rodrigo Sanz; Melone, Sirio; Rueda, Jose A; Brandariz, Lorena; Valverde, Ignacio; Arredondo, Jorge; Pastor, Carlos; Garcia-Olmo, Damian; Malats, Nuria; Urioste, Miguel; Gonzalez-Sarmiento, Rogelio; Spinelli, Antonino; Holowatyj, Andreana N

Affiliations

Fdn Jimenez Diaz UTE, Surg Dept, Madrid, Spain - Author
Galdacano Hosp, Surg Dept, Galdakao, Spain - Author
Gen Univ Hosp Gregorio Maranon, Surg Dept, Madrid, Spain - Author
Hosp Clin Barcelona, Gastroenterol Dept, Barcelona, Spain - Author
Hosp Mar, Surg Dept, Barcelona, Spain - Author
Hosp Univ 12 Octubre, Surg Dept, Madrid, Spain - Author
Hosp Univ Fdn Alcorcon, Surg Dept, Madrid, Spain - Author
Hosp Univ Infanta Leonor, Surg Dept, Madrid, Spain - Author
Humanitas Univ, Rozzano, Lombardia, Italy - Author
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain - Author
IRCCS Humanitas Res Hosp, Rozzano, Lombardia, Italy - Author
La Paz Univ Hosp, Surg Dept, Madrid, Spain - Author
MD Anderson Canc Ctr Madrid, Surg Dept, Madrid, Spain - Author
Nanderbilt Ingram Canc Ctr, Nashville, TN USA - Author
Ramon Y Cajal Univ Hosp, Surg Dept, Madrid, Spain - Author
San Carlos Univ Hosp, Surg Dept, Madrid, Spain - Author
Spanish Natl Canc Res Ctr, Madrid, Spain - Author
Univ Autonoma Madrid, Madrid, Spain - Author
Univ Hosp Ctr Leon, Surg Dept, Leon, Spain - Author
Univ Hosp Salamanca, Oncol Dept, Castilla, Spain - Author
Univ Hosp Salamanca, Oncol Dept, Leon, Spain - Author
Univ Hosp Salamanca, Oncol Dept, Salamanca, Spain - Author
Univ Hosp Salamanca, Surg Dept, Castilla, Spain - Author
Univ Hosp Salamanca, Surg Dept, Leon, Spain - Author
Univ Hosp Salamanca, Surg Dept, Salamanca, Spain - Author
Univ Navarra Clin, Surg Dept, Madrid, Spain - Author
Univ Salamanca, Med Dept, Salamanca, Spain - Author
Vall Hebron Univ Hosp, Surg Dept, Barcelona, Spain - Author
Vanderbilt Univ, Med Ctr, Nashville, TN USA - Author
Villalba Gen Hosp, Surg Dept, Collado Villalba, Spain - Author
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Abstract

Purpose The Spanish Early-onset Colorectal Cancer (SECOC) study is a multicentre prospective cohort established in Spain to investigate the molecular basis of early-onset colorectal cancer (EOCRC), including metabolic alterations. Participants 220 patients with EOCRC have been enrolled since January 2019 through 18 centres across Spain. Individual-level data were collected by questionnaire, including lifestyle and other colorectal cancer-related factors. Medical record review was performed to capture clinical, histopathological and familial cancer history data. Biospecimen collection (blood, stool, tissue) at diagnosis and at various time points across treatment, as applicable, is also completed. Findings to date Participants had a median age of 44 years (range 14-49), and the majority are men (60%), with individuals age 40-49 years at EOCRC diagnosis being over-represented. Forty-three per cent of participants were diagnosed with a tumour in the rectosigmoid junction/rectum. Nearly two-thirds of EOCRC cases (64%) were diagnosed with advanced stage (III-IV) disease, and 28% of cases had no reported familial history of cancer. Future plans We are actively recruiting and observing participants; we plan to administer follow-up questionnaires and perform additional biospecimen collection. This prospective cohort offers a unique, rich resource for research on EOCRC aetiologies and will contribute to larger international efforts to disentangle the rising disease burden.

Keywords

AdultAgeAnthropometryArticleBody massCancer diagnosisCancer geneticsCancer stagingCarbohydrateCarbohydrate metabolismCarcinogenesisClinical featureCohort analysisColonColorectal cancerColorectal carcinomaColorectal surgeryDemographyEarly cancerFemaleFollow upGastrointestinal tumoursHereditary tumor syndromeHistopathologyHumanLifestyle modificationMajor clinical studyMaleMedical record reviewMetabolic disorderMicrosatellite instabilityMulticenter studyMultiple cancerNeoadjuvant therapyProspective studyQuestionnaireRectum hemorrhageSpainTranscriptomicsTumor volume

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Bmj Open due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.06, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 4
  • Scopus: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 15.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 17.65.
  • The number of mentions on the social network X (formerly Twitter): 12 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy; United States of America.