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Analysis of institutional authors

Valero, JgAuthor

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April 7, 2022
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Active Fragments from Pro- and Antiapoptotic BCL-2 Proteins Have Distinct Membrane Behavior Reflecting Their Functional Divergence

Publicated to: Plos One. 5 (2): - 2010-02-05 5(2), DOI: 10.1371/journal.pone.0009066

Authors:

Guillemin, Y; Lopez, J; Gimenez, D; Fuertes, G; Valero, JG; Blum, L; Gonzalo, P; Salgado, J; Girard-Egrot, A; Aouacheria, A
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Affiliations

Univ Lyon, CNRS, ICBMS, UMR5246, Villeurbanne, France - Author
Univ Lyon, IBCP, CNRS, UMR5086, Lyon, France - Author
Univ Valencia, Dept Bioquim & Biol Mol, Valencia, Spain - Author
Univ Valencia, ICMol, Valencia, Spain - Author
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Abstract

Background: The BCL-2 family of proteins includes pro-and antiapoptotic members acting by controlling the permeabilization of mitochondria. Although the association of these proteins with the outer mitochondrial membrane is crucial for their function, little is known about the characteristics of this interaction. Methodology/Principal Findings: Here, we followed a reductionist approach to clarify to what extent membrane-active regions of homologous BCL-2 family proteins contribute to their functional divergence. Using isolated mitochondria as well as model lipid Langmuir monolayers coupled with Brewster Angle Microscopy, we explored systematically and comparatively the membrane activity and membrane-peptide interactions of fragments derived from the central helical hairpin of BAX, BCL-xL and BID. The results show a connection between the differing abilities of the assayed peptide fragments to contact, insert, destabilize and porate membranes and the activity of their cognate proteins in programmed cell death. Conclusion/Significance: BCL-2 family-derived pore-forming helices thus represent structurally analogous, but functionally dissimilar membrane domains.
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Keywords

antimicrobial peptidesbax-derived peptidecytochrome-c releaseindependent mechanismslangmuir-monolayerlipid-membranesmitochondrial-membranepore formationx-lAntimicrobial peptidesBax-derived peptideBrewster-angle microscopyCytochrome-c releaseIndependent mechanismsLangmuir-monolayerLipid-membranesMitochondrial-membranePore formationX-l

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PLoS One due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2010, it was in position 12/86, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-04:

  • WoS: 24
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 40.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 40 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France.

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Awards linked to the item

This work was supported by grants from La Ligue Contre le Cancer (Comites de la Drome et du Rhone), La Fondation d'Entreprise SILAB -Jean PAUFIQUE, the Spanish MEC (BFU2007-67097) and a collaborative French/Spanish project (EGIDE PHC PICASSO 17092SM; MEC, HF2007-0090). YG is a recipient of an MRT (Ministere de la Recherche des Sciences et Techniques) fellowship. JL is supported by Hospices Civils de Lyon. JGV is recipient of doctoral fellowship from La Region Rhone-Alpes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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