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Analysis of institutional authors

Chiva-Blanch GAuthorGiró OAuthorCofán MAuthorGomis RAuthorJimenez AAuthorOrtega ECorresponding Author

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April 13, 2022
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Article

Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes

Publicated to: Nutrients. 14 (7): 1368- - 2022-04-01 14(7), DOI: 10.3390/nu14071368

Authors:

Chiva-Blanch, Gemma; Giro, Oriol; Cofan, Montserrat; Calle-Pascual, Alfonso L; Delgado, Elias; Gomis, Ramon; Jimenez, Amanda; Franch-Nadal, Josep; Rojo Martinez, Gemma; Ortega, Emilio
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Affiliations

Catalan Inst Hlth, GEDAPS Network, IDIAP Jordi Gol Fdn, Primary Care Res Support Unit,EAP Raval Sud, Barcelona 08001, Spain - Author
Hosp Clin Barcelona, August Pi i Sunyer Biomed Res Inst IDIBAPS, Dept Endocrinol & Nutr, Barcelona 08036, Spain - Author
Inst Salud Carlos III, Spanish Biomed Res Network Diabet & Associated Me, Madrid 28029, Spain - Author
Inst Salud Carlos III, Spanish Biomed Res Network Physiopathol Obes & Nu, Madrid 28029, Spain - Author
Inst Salud Carlos III, Spanish Biomed Res Network Rare Dis CIBERER, Madrid 28029, Spain - Author
Reg Univ Hosp Malaga, Biomed Res Inst Malaga IBIMA, Endocrinol & Nutr Dept, Malaga 29010, Spain - Author
San Carlos Univ Hosp Madrid, Dept Endocrinol & Nutr, Madrid 28040, Spain - Author
Univ Oviedo, Cent Univ Hosp Asturias, Hlth Res Inst Principal Asturias ISPA, Dept Endocrinol & Nutr, Oviedo 33011, Spain - Author
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Abstract

The identification of nutritional patterns associated with the development of type 2 diabetes (T2D) might help lead the way to a more efficient and personalized nutritional intervention. Our study is aimed at evaluating the association between fatty acids (FA) in red blood cell (RBC) membranes, as a quantitative biomarker of regular dietary fat intake, and incident type 2 diabetes in a Spanish population. We included 1032 adult Spaniards (57% women, age 49 ± 15 years, 18% prediabetes), without diabetes at study entry, from the Di@bet.es cohort. Incident diabetes was diagnosed at the end of the study follow-up. The FA percentage in RBC was determined at baseline by gas chromatography. Participants were followed on average 7.5 ± 0.6 years. Lower percentages of linoleic acid (LA), ?-linolenic (ALA), and eicosapentaenoic acid (EPA), and higher percentages of docosahexaenoic acid (DHA) in RBC membranes were associated, independently of classical risk factors, with worse glucose metabolism at the end of the study follow-up. In addition, higher percentages of ALA and EPA, and moderate percentages of DHA, were associated with lower risk of diabetes. No significant associations were found for LA and diabetes risk. Dietary patterns rich in vegetables are independently associated with lower risk of both deterioration of glucose regulation and incident diabetes, and should be reinforced for the prevention of diabetes.
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Keywords

acid biomarkersadipose-tissuealpha-linolenic acidfatty acidslinoleic acidmetaanalysisomega-3 fatty acidsomega-3-fatty-acidsrisktype 2 diabetesworse of glucose metabolismAdultAlpha-linolenic acidArticleCohort analysisControlled studyDiabetes mellitus, type 2Dietary patternDocosahexaenoic acidDocosahexaenoic acidsEicosapentaenoic acidErythrocyteErythrocyte membraneErythrocytesFat intakeFatty acidFatty acidsFatty acids, omega-3FemaleFish consumptionFollow upGas chromatographyGlucoseGlucose metabolismHumanHuman cellHumansIcosapentaenoic acidImpaired glucose toleranceIncidenceLinoleic acidLinolenic acidMajor clinical studyMaleMetabolismMiddle agedNon insulin dependent diabetes mellitusOmega 3 fatty acidOmega-3 fatty acidsQuantitative analysisRisk factorSpainType 2 diabetesVegetableVegetable consumptionVegetablesWorse of glucose metabolism

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 17/88, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-01:

  • WoS: 2
  • Scopus: 3
  • Europe PMC: 1
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 19.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 17 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Chiva Blanch, Gemma) and Last Author (Ortega Martinez de Victoria, Emilio).

the author responsible for correspondence tasks has been Ortega Martinez de Victoria, Emilio.

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Awards linked to the item

This research was funded by the Spanish Ministry of Health (ISCIII) and FEDER, grant number CB06/03/0017. The study was supported by the Spanish Biomedical research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM; ISCIII Ministerio de Ciencia e Innovacion), Ministerio de Sanidad y Consumo and the Spanish Society of Diabetes (SED). G.R-M. is supported by Nicolas Monardes program of the Consejeria de Salud de la Junta de Andalucia (C-0060-2012).
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