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Balsells-Vives SAuthorSan Bartolomé CAuthorCasas-Saucedo RAuthorRuano-Zaragoza MAuthorBartra JAuthorMunoz-Cano RAuthorPascal MAuthor
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Article

Low Levels Matter: Clinical Relevance of Low Pru p 3 sIgE in Patients With Peach Allergy

Publicated to:Frontiers In Allergy. 3 868267-868267 - 2022-04-05 3(), DOI: 10.3389/falgy.2022.868267

Authors: Balsells-Vives, Sara; San Bartolome, Clara; Casas-Saucedo, Rocio; Ruano-Zaragoza, Maria; Rius, Josefina; Torradeflot, Maria; Bartra, Joan; Munoz-Cano, Rosa; Pascal, Mariona

Affiliations

Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. - Author
Department of Immunology, Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic de Barcelona, Barcelona, Spain. - Author
Hosp Clin Barcelona, Ctr Diagnost Biomed CDB, Dept Immunol, Barcelona, Spain - Author
Hosp Clin Barcelona, Inst Clin Resp ICR, Dept Pneumol, Allergy Sect, Barcelona, Spain - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Clin & Expt Resp Immunoallergy IRCE, Barcelona, Spain - Author
Inst Salud Carlos III, Spanish Res Network Allergy ARADyAL, Red Nacl Alergia Asma Reacc Adversas & Alerg, Madrid, Spain - Author
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Abstract

Many clinical lab settings still use 0.35 KUA/L as the cut-off for serum specific-IgE (sIgE) immunoassays, while the detection limit is 0.1 KUA/L. The clinical relevance of -low-level sIgE (0.1-0.35 KUA/L) remains controversial. Pru p 3 sIgE is considered to be the main routine tool for assessing lipid transfer protein (LTP) sensitization. We aimed to evaluate the clinical relevance of Pru p 3 sIgE low levels in a population diagnosed with LTP allergy. Adults diagnosed with LTP allergy and Pru p 3 sIgE ? 0.1 KUA/L between 2012 and 2019 were included. Clinical data were reviewed. nPru p 3 basophil activation test (BAT) was performed and basophil reactivity (BR) and sensitivity (BS) correlated with the peach allergy symptoms. Pru p 3 sIgE from 496 subjects was recorded, 114 (23.0%) between 0.1 and 0.34 KUA/L (grLOW), the rest ? 0.35 KUA/L (grB). A total of 44.7% in grLOW and 59.9% in grB were allergic. Urticaria was more frequent in grLOW. In grLOW, Pru p 3 sIgE was higher in patients with local compared with systemic symptoms. In grB, Pru p 3 sIgE was higher in allergic patients. Pru p 3/Total IgE ratios were higher in allergic vs. tolerant in both groups. In BAT, BR was similar in both groups. In grLOW, it was higher on allergic compared with tolerant (p = 0.0286), and on those having systemic vs. local symptoms (p = 0.0286). BS showed no significant difference between groups. Patients with low levels represent a non-negligible fraction and around 45% are peach allergic. BAT showed functional sIgE in them. Pru p 3 sensitizations should be carefully evaluated even when sIgE levels are low.Copyright © 2022 Balsells-Vives, San Bartolomé, Casas-Saucedo, Ruano-Zaragoza, Rius, Torradeflot, Bartra, Munoz-Cano and Pascal.

Keywords
BatClinical relevanceLipid transfer proteinLow levelsSerum specific-ige

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers In Allergy, Q4 Agency Scopus (SJR), its regional focus and specialization in Immunology and Allergy, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.81, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-15, the following number of citations:

  • WoS: 9
  • Scopus: 9
  • Europe PMC: 2
  • OpenCitations: 4
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-15:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 18.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 18 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Balsells Vives, Sara) and Last Author (Pascal Capdevila, Mariona).