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Analysis of institutional authors

Bantulà MCorresponding AuthorTubita VAuthorRoca-Ferrer JAuthorMullol JAuthorValero AAuthorBobolea IAuthorPascal MAuthorDe Hollanda AAuthorVidal JAuthorPicado CAuthorArismendi EAuthor

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September 15, 2022
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Article

Weight loss and vitamin D improve hyporesponsiveness to corticosteroids in obese asthma

Publicated to:Journal Of Investigational Allergology And Clinical Immunology. 33 (6): 464-473 - 2023-01-01 33(6), DOI: 10.18176/jiaci.0861

Authors: Bantula, M; Tubita, V; Roca-Ferrer, J; Mullol, J; Valero, A; Bobolea, I; Pascal, M; de Hollanda, A; Vidal, J; Picado, C; Arismendi, E

Affiliations

Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain - Author
Ctr Invest Biomed Red Enfermedades Respiratorias C, Madrid, Spain - Author
Ctr Invest Biomed Red Fisopatol Obes & Nutr CIBERO, Madrid, Spain - Author
Hosp Clin Barcelona, Endocrinol & Nutr Dept, Obes Unit, Barcelona, Spain - Author
Hosp Clin Barcelona, ENT Dept, Rhinol Unit & Smell Clin, Barcelona, Spain - Author
Hosp Clin Barcelona, Immunol Dept, Barcelona, Spain - Author
Hosp Clin Barcelona, Pulmonol & Allergy Dept, Barcelona, Spain - Author
Inst Invest Biomed August Pi i Sunyer IDIBAPS, C Casanova 143, Barcelona 08036, Spain - Author
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Abstract

Obesity negatively impacts on asthma response to inhaled corticosteroids by unknown mechanisms. Objective: To demonstrate that the poor response to inhaled corticosteroids in obese asthma is associated with an impaired anti-inflammatory activity of corticosteroids and vitamin D deficiency, both improved by weight loss.23 obese asthmatics (OA) [18 females; median age (interquartile range) 56 (51-59) years], 14 non-obese asthmatics (NOA) [11 females; 53 (43-60) years], 15 obese (O) [13 females; 47 (45-60) years], and 19 healthy controls (HC) [14 females; 43 (34-56) years] were enrolled. 10 OA and 11 O patients were evaluated at baseline (V1) and six months after (V2) bariatric surgery. Corticosteroid response was measured by dexamethasone inhibition of peripheral blood mononuclear cell (PBMC) proliferation. Lung function, serum levels of leptin, adiponectin, and vitamin D were measured at V1 and V2.We found a reduced response to dexamethasone in PBMCs of O and OA patients with respect to NOA and HC subjects, that inversely correlated with the diponectin/leptin ratio and vitamin D levels. Bariatric surgery improved corticosteroid responses in O and OA patients and normalized adiponectin/leptin ratio and vitamin D levels. Exposure of PBMCs to vitamin D potentiated the antiproliferative effects of corticosteroids. Dexamethasone and vitamin D induced similar MKP-1 expression in O and OA patients.We found a reduced response to dexamethasone in PBMCs of O and OA patients with respect to NOA and HC subjects, that inversely correlated with the adiponectin/leptin ratio and vitamin D levels. Bariatric surgery improved corticosteroid responses in O and OA patients and normalized adiponectin/leptin ratio and vitamin D levels. Exposure of PBMCs to vitamin D potentiated the antiproliferative effects of corticosteroids. Dexamethasone and vitamin D induced similar MKP-1 expression in O and OA patients.

Keywords

25 hydroxyvitamin dAdiponectinAdrenal cortex hormonesAdultAnti-inflammatory agentsAntiinflammatory activityAntiinflammatory agentAntiproliferative activityArticleAsthmaBariatric surgeryBeta 2 microglobulinBody weight lossBronchodilating agentCarboxyfluorescein diacetate succinimidyl esterCd4 antibodyCd4+ t lymphocyteCell cultureCell isolationCell proliferationCell viability assayChemiluminescence immunoassayClinical articleComplicationConsciousness disorderControlled studyCorticosteroidCurrent smokerDexamethasoneDisease exacerbationDisease severityEosinophil countFemaleFlow cytometryFluorescence activated cell sortingForced expiratory volumeForced vital capacityGene expressionHumanHuman cellHumansHyporesponsivenessHypoxanthine phosphoribosyltransferaseIc50Immunoglobulin eLeptinLeukocytes, mononuclearLung functionMaleMethacholineMiddle agedMitogen activated protein kinase phosphatase 1Mononuclear cellNon-smokerObesityPeripheral blood mononuclear cellPhysiologyPhytohemagglutininReal time reverse transcription polymerase chain reactionRoux-en-y gastric bypassSalbutamolSleeve gastrectomyVitamin dVitamin d deficiencyWeight loss

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Investigational Allergology And Clinical Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 5/39, thus managing to position itself as a Q1 (Primer Cuartil), in the category Allergy.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.61. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 7.25 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-09, the following number of citations:

  • WoS: 8
  • Scopus: 7
  • Europe PMC: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-09:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 10.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 21 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Bantulà Fonts, Marina) and Last Author (Arismendi Nuñez, Ebymar).

the author responsible for correspondence tasks has been Bantulà Fonts, Marina.