High incidence of PTSD diagnosis and trauma-related symptoms in a trauma exposed bipolar I and II sample

November 8, 2022

Publications

>

Article

Sí

Publicated to: Frontiers In Psychiatry. 13 931374- - 2022-10-20 13(), DOI: 10.3389/fpsyt.2022.931374

Authors: Hogg, B; Valiente-Gómez, A; Redolar-Ripoll, D; Gardoki-Souto, I; Fontana-McNally, M; Lupo, W; Jiménez, E; Madre, M; Blanco-Presas, L; Reinares, M; Cortizo, R; Massó-Rodriguez, A; Castaño, J; Argila, I; Castro-Rodríguez, JI; Comes, M; Doñate, M; Herrería, E; Macias, C; Mur, E; Novo, P; Rosa, AR; Vieta, E; Radua, J; Padberg, F; Pérez-Solà, V; Moreno-Alcázar, A; Amann, BL

Affiliations

Addictive Behaviours Unit, Psychiatry Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. - Author

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto Carlos III, Madrid, Spain. - Author

Day Hosp, Ctr Psicoterapia Barcelona CPB, Barcelona, Spain - Author

Fed Univ Rio Grande Do Sul UFRGS, Postgrad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil - Author

FIDMAG Germanes Hospitalaries Res Fdn, Barcelona, Spain - Author

FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain. - Author

Hosp Benito Menni CASM, Barcelona, Spain - Author

Hosp Clin Barcelona, Inst Neurociencias ICN, Programa TEPT AGRESX, Barcelona, Spain - Author

Hosp Clin Porto Alegre HCPA, Lab Mol Psychiat, Porto Alegre, RS, Brazil - Author

Hosp del Mar Med Res Inst IMIM, Barcelona, Spain - Author

Hosp Santa Creu & Sant Pau, Addict Behav Unit, Psychiat Dept, Barcelona, Spain - Author

Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. - Author

Inst Brain, Neuromodulat Unit, Barcelona, Spain - Author

Inst Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain - Author

Karolinska Inst KI, Dept Clin Neurosci, Solna, Sweden - Author

Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England - Author

Klinikum Univ Munchen, Clin Psychiat & Psychotherapy, Munich, Germany - Author

Parc Salut Mar, Inst Neuropsychiat & Addict INAD, Ctr Emili Mira, Barcelona, Spain - Author

Parc Salut Mar, Inst Neuropsychiat & Addict INAD, Ctr Forum Res Unit, Barcelona, Spain - Author

Parc Salut Mar, Inst Neuropsychiat & Addict INAD, Ctr Salud Mental Adultos CSMA, Barcelona, Spain - Author

Parc Salut Mar, Inst Neuropsychiat & Addict INAD, Ctr Salud Mental Infantil & Juvenil CSMIJ, Barcelona, Spain - Author

Parc Sanitari St Joan de Deu, St Boi De Llobegrat, Spain - Author

Parc Sanitari St Joan Deu, Ctr Salud Mental Adultos Ciutat Vella, Barcelona, Spain - Author

PhD Programme, Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. - Author

Univ Autonoma Barcelona, Dept Psychiat & Forens Med, PhD Programme, Barcelona, Spain - Author

Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Bipolar & Depress Disorders Unit, Barcelona, Spain - Author

Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Farmacol, Porto Alegre, RS, Brazil - Author

Univ Oberta Catalunya UOC, Fac Psychol & Educ Sci, Cognit NeuroLab, Barcelona, Spain - Author

Univ Pompeu Fabra, Dept Med & Ciencias Vida, Barcelona, Spain - Author

Abstract

Background: Post-traumatic stress disorder (PTSD) is an established comorbidity in Bipolar Disorder (BD), but little is known about the characteristics of psychological trauma beyond a PTSD diagnosis and differences in trauma symptoms between BD-I and BD-II.Objective: (1) To present characteristics of a trauma-exposed BD sample; (2) to investigate prevalence and trauma symptom profile across BD-I and BD-II; (3) to assess the impact of a lifetime PTSD diagnosis vs. a history of trauma on BD course; and (4) to research the impacts of sexual and physical abuse.Methods: This multi-center study comprised 79 adult participants with BD with a history of psychological trauma and reports baseline data from a trial registered in Clinical Trials (https://clinicaltrials.gov; ref: NCT02634372). Clinical variables were gathered through clinical interview, validated scales and a review of case notes.Results: The majority (80.8%) of our sample had experienced a relevant stressful life event prior to onset of BD, over half of our sample 51.9% had a lifetime diagnosis of PTSD according to the Clinician Administered PTSD scale. The mean Impact of Event Scale-Revised scores indicated high levels of trauma-related distress across the sample, including clinical symptoms in the PTSD group and subsyndromal symptoms in the non-PTSD group. Levels of dissociation were not higher than normative values for BD. A PTSD diagnosis (vs. a history of trauma) was associated with psychotic symptoms [2(1) = 5.404, p = 0.02] but not with other indicators of BD clinical severity. There was no significant difference between BD-I and BD-II in terms of lifetime PTSD diagnosis or trauma symptom profile. Sexual abuse significantly predicted rapid cycling [2(1) = 4.15, p = 0.042], while physical abuse was not significantly associated with any clinical indicator of severity.Conclusion: Trauma load in BD is marked with a lack of difference in trauma profile between BD-I and BD-II. Although PTSD and sexual abuse may have a negative impact on BD course, in many indicators of BD severity there is no significant difference between PTSD and subsyndromal trauma symptoms. Our results support further research to clarify the role of subsyndromic PTSD symptoms, and highlight the importance of screening for trauma in BD patients.

Keywords

childhood maltreatmentclinical characteristicscognitive functiondissociationenvironmental riskeye-movement desensitizationlife eventsphysical abuse and neglectpsychological traumapsychometric propertiesptsd-post-traumatic stress disorderrating-scale bdrssexual abusespanish versionAbús sexual envers els infantsAbuseAdultAntidepressant agentAnxiolytic agentArticleBipolar depression rating scaleBipolar disorderBipolar i disorderBipolar ii disorderChild sexual abuseClinical featureClinical researchControlled studyDisease associationDisease courseDisease severityDissociació (química)DissociationDsm-ivFemaleHumanImpact of events scaleIncidenceInterviewLifespanMajor clinical studyMaleMaltractamentManic-depressive illnessMedical historyMedical record reviewMood stabilizerMulticenter study (topic)NeglectNeuroleptic agentPersonal experiencePhysical abusePhysical abuse and neglectPost-traumatic stress disorderPosttraumatic stress disorderPosttraumatic-stress-disorderPredictionPrevalencePsychological traumaPsychosisPtsd—post-traumatic stress disorderRating scaleSexual abuseSubsyndromal symptomSymptomTrastorn bipolarTrastorn per estrès posttraumàticTrauma related symptomTraumes psíquics

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers In Psychiatry due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Psychiatry and Mental Health.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-15:

WoS: 5
Scopus: 4
Europe PMC: 2

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Brazil; Germany; Sweden; United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Bladé Creixenti, Joan) .

Awards linked to the item

This work was supported by a grant for BA from the Plan Nacional de I + D + i and co-funded by the Instituto de Salud Carlos III-Subdireccion General de Evaluacion y Fomento de la Investigacion, Plan Nacional 2008-2011 with the following Research Project (PI/15/02242). Furthermore, BA has been supported by a NARSARD Independent Investigator Grant from the Brain and Behavior Research Foundation (Number: 24397).

Indexed in

License and Use

Citations

Altmetrics

Analysis of institutional authors

Share