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Analysis of institutional authors

Soriano ACorresponding AuthorMensa JAuthor

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November 16, 2022
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Mechanism of action of cefiderocol

Publicated to: Revista Espanola de Quimioterapia. 35 Suppl 2 (Suppl 2): 16-19 - 2022-09-01 35 Suppl 2(Suppl 2), DOI: 10.37201/req/s02.02.2022

Authors:

Soriano, A; Mensa, J
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Affiliations

- Author
Alex Soriano, Servicio de Enfermedades Infecciosas, Hospital Clínic de Barcelona, Universidad de Barcelona, Spain. asoriano@clinic.cat. - Author
Univ Barcelona, Hosp Clin Barcelona, Serv Enfermedades Infecciosas, IDIBAPS - Author
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Abstract

Gram-negative bacilli are intrinsically resistant to many antibiotics due to the low permeability of their outer membrane. The most effective strategy to solve this problem has been the design of antibiotics that cross the membrane using specific transport systems. This is the case of cefiderocol, which, unlike cefepime or ceftazidime, has a chlorocatechol group at the end of the C-3 side chain. This group is recognized by transporters located in the outer membrane that allow cefiderocol to accumulate in the periplasmic space. Furthermore, cefiderocol is not a substrate for efflux pumps and the configuration of the side chains at C-7 and in particular at C-3 confer it a high stability against hydrolysis by most beta-lactamases of clinical interest including class A (KPC, BLEEs), C (ampC) or D (OXA-48) serine beta-lactamases and metallo-betalactamases (NDM, VIM. IMP). In order to better understand the mechanism of action of cefiderocol, the importance of iron in bacterial metabolism and the competition for iron between bacteria and host are reviewed.
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Keywords

AnimalAnimalsAnti-bacterial agentsAntibacterial activityAntiinfective agentArticleAztreonamBacterial metabolismBeta lactamaseBeta lactamase ampcBeta lactamase inhibitorBeta lactamase kpcBeta-lactamase inhibitorsBeta-lactamasesBovineCarbapenem derivativeCarbapenemsCattleCefepimeCefiderocolCeftazidimeCephalosporin derivativeCephalosporinsChemistryChloramphenicolD 13 9001Drug accumulationDrug mechanismDrug stabilityDrug structureEscherichia coliGram negative bacteriumGram negative infectionGram-negativeGram-negative bacteriaHost bacterium interactionHumanHydrolysisInosine monophosphateInosine phosphateIronMechanism of actionMetabolismMetallo beta lactamaseNonhumanOuter membranePeriplasmPseudomonas aeruginosaQuinolone derivativeQuinolonesSerineSerine beta lactamaseSiderophorSiderophoreSpr 206Structure analysisTetracyclineTetracycline derivativeTetracyclinesUnclassified drug

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Revista Espanola de Quimioterapia, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Pharmacology & Pharmacy, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.24. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-06, the following number of citations:

  • WoS: 22
  • Scopus: 7
  • Europe PMC: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 60.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 59 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Additionally, the work has been submitted to a journal classified as Diamond in relation to this type of editorial policy.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Soriano Viladomiu, Alex) and Last Author (Mensa Pueyo, Josep).

the author responsible for correspondence tasks has been Soriano Viladomiu, Alex.

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