MRI Investigation of the Differential Impact of Left Ventricular Ejection Fraction After Myocardial Infarction in Elderly vs. Nonelderly Patients to Predict Readmission for Heart Failure

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This work was supported by Instituto de Salud Carlos III and Fondos Europeos de Desarrollo Regional FEDER (grant numbers PI20/00637, PI15/00531, and CIBERCV16/11/00486, CIBERCV16/11/00420, CIBERCV16/11/00479, and CM21/00175 to V.M.-G.), Fundacio La Marato TV3 (grant 20153030-31-32), La Caixa Banking Foundation (HR17-00527) and by Conselleria de Educacion - Generalitat Valenciana (PROMETEO/2021/008). J.G. acknowledges financial support from the Agencia Estatal de Investigacion (grant FJC2020-043981-I/AEI/10.13039/501100011033).

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Lorenzatti DAuthorDomenech-Ximenos BAuthorOrtiz-Pérez JtAuthor

February 8, 2023

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Article

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Publicated to:Journal Of Magnetic Resonance Imaging. 58 (5): 1507-1518 - 2023-11-01 58(5), DOI: 10.1002/jmri.28632

Authors: Marcos-Garcés, V; Merenciano-González, H; Gabaldón-Pérez, A; Nuñez, J; Chorro, FJ; Bodí, V; Gavara, J; Pérez, N; Ríos-Navarro, C; López-Lereu, MP; Monmeneu, JV; de Dios, E; Rodríguez-Palomares, JF; Lorenzatti, D; Domenech-Ximenos, B; Morr, CI; Ortiz-Pérez, JT

Affiliations

ASCIRES Biomed Grp, Cardiovasc Magnet Resonance Unit, Valencia, Spain - Author

Cardiovascular Institute, Hospital Clínic, Barcelona, Spain. - Author

Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, Spain. - Author

Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain. - Author

Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain - Author

Department of Cardiology, Hospital Clínico Universitario de Valencia, Valencia, Spain. - Author

Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain. - Author

Hosp Clin Barcelona, Cardiothorac Imaging Diagnost Imaging Ctr, Barcelona, Spain - Author

Hosp Clin Barcelona, Cardiovasc Inst, Barcelona, Spain - Author

Hosp Clin Univ Valencia, Dept Cardiol, Valencia, Spain - Author

Hosp Univ Vall Dhebron, Dept Cardiol, Valencia, Spain - Author

Hospital Universitari Vall d'Hebron, Department of Cardiology, Barcelona, Spain. - Author

INCLIVA Hlth Res Inst, Valencia, Spain - Author

Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain - Author

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. - Author

Univ Autonoma Barcelona, Barcelona, Spain - Author

Univ Politecn Valencia, Ctr Biomat & Tissue Engn, Valencia, Spain - Author

Univ Valencia, Fac Med & Odontol, Valencia, Spain - Author

Universitat Autonoma de Barcelona, Barcelona, Spain. - Author

Vall d'Hebrón Institut de Recerca (VHIR), Barcelona, Spain. - Author

Vall dHebron Inst Recerca VHIR, Barcelona, Spain - Author

Abstract

Patients with ST-segment elevation myocardial infarction (STEMI), especially elderly individuals, have an increased risk of readmission for acute heart failure (AHF).To study the impact of left ventricular ejection fraction (LVEF) by MRI to predict AHF in elderly (>70?years) and nonelderly patients after STEMI.Prospective.Multicenter registry of 759 reperfused STEMI patients (23.3% elderly).1.5-T. Balanced steady-state free precession (cine imaging) and segmented inversion recovery steady-state free precession (late gadolinium enhancement) sequences.One-week MRI-derived LVEF (%) was quantified. Sequential MRI data were recorded in 579 patients. Patients were categorized according to their MRI-derived LVEF as preserved (p-LVEF, ?50%), mildly reduced (mr-LVEF, 41%-49%), or reduced (r-LVEF, ?40%). Median follow-up was 5 [2.33-7.54] years.Univariable (Student's t, Mann-Whitney U, chi-square, and Fisher's exact tests) and multivariable (Cox proportional hazard regression) comparisons and continuous-time multistate Markov model to analyze transitions between LVEF categories and to AHF. Hazard ratios (HR) with 95% confidence intervals (CIs) were computed. P?

Keywords

30-dayacute heart failureelderlyleft ventricular ejection fractionmortalityoutcomespercutaneous coronary interventionprognostic valuetrendsAcute heart failureAcute myocardial infarctionAdultAgedArticleCardiac magnetic-resonanceClinical featureClinical trialComplicationContrast enhancementContrast mediaContrast mediumDiagnostic imagingElderlyFemaleFollow upGadoliniumHeart failureHeart infarctionHeart left ventricle ejection fractionHeart left ventricle functionHeart stroke volumeHospital readmissionHumanHumansLeft ventricular ejection fractionMagnetic resonance imagingMajor clinical studyMaleMiddle agedMulticenter studyMyocardial infarctionNuclear magnetic resonance imagingPatient readmissionPredictionProceduresPrognosisProspective studiesProspective studyRisk factorSt elevation myocardial infarctionSt segment elevation myocardial infarctionStroke volumeVentricular function, left

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF MAGNETIC RESONANCE IMAGING due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 42/204, thus managing to position itself as a Q1 (Primer Cuartil), in the category Radiology, Nuclear Medicine & Medical Imaging.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-16: