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Analysis of institutional authors

Vega-Beyhart AAuthorHanzu FaAuthorCasals GCorresponding Author

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March 2, 2023
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Cortisol: Analytical and clinical determinants

Publicated to: Advances In Clinical Chemistry. 113 235-271 - 2023-01-01 113(), DOI: 10.1016/bs.acc.2022.11.005

Authors: Vega-Beyhart, Arturo; Araujo-Castro, Marta; Hanzu, Felicia A; Casals, Gregori

Affiliations

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain - Author
Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain - Author
Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain. - Author
Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. - Author
Hosp Clin Barcelona, Dept Endocrinol & Nutr - Author
Inst Invest Biomed Ramon y Cajal IRYCIS - Author
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain - Author
Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain. - Author
Univ Barcelona, Dept Fundamental Care & Med Surg Nursing, Fac Med & Hlth Sci - Author
Univ Barcelona, Dept Med, Fac Med & Hlth Sci - Author
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Abstract

Cortisol, the main human glucocorticoid, is synthesized from cholesterol in the adrenal cortex and predominantly metabolized by the liver. Interpretation of quantitative results from the analysis of serum, urine and saliva is complicated by variation in circadian rhythm, response to stress as well as the presence of protein-bound and free forms. Interestingly, cortisol is the only hormone routinely measured in serum, urine, and saliva. Preanalytical and analytical challenges arise in each matrix and are further compounded by the use of various stimulation and suppression tests commonly employed in clinical practice. Although not yet included in clinical guidelines, measurement of cortisol in hair may be of interest in specific situations. Immunoassays are the most widely used methods in clinical laboratories to measure cortisol, but they are susceptible to interference from synthetic and endogenous steroids, generally producing a variable overestimation of true cortisol results, especially in urine. Analysis by mass spectrometry provides higher specificity and allows simultaneous measurement of multiple steroids including synthetic steroids, thus reducing diagnostic uncertainty. An integrated review of cortisol in various disease states is also addressed. © 2023 Elsevier Inc.

Keywords

Adrenal insufficiencyBody fluidBody fluidsCortisolCushing's syndromeDexamethasone suppression testHumanHumansHydrocortisoneImmunoassayLiverMass spectrometrySalivaSerumUrine free cortisol

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Advances In Clinical Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-05:

  • WoS: 3
  • Scopus: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 27.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 27 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 14.
  • The number of mentions on the social network X (formerly Twitter): 23 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Vega Beyhart, Arturo) and Last Author (Casals Mercadal, Gregori).

the author responsible for correspondence tasks has been Casals Mercadal, Gregori.