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Martín-Ontiyuelo CAuthor

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Nitrosative and Oxidative Stress, Reduced Antioxidant Capacity, and Fiber Type Switch in Iron-Deficient COPD Patients: Analysis of Muscle and Systemic Compartments

Publicated to:Nutrients. 15 (6): 1454-1454 - 2023-03-01 15(6), DOI: 10.3390/nu15061454

Authors: Pérez-Peiró, M; Miranda, MA; Rodríguez-Chiaradía, DA; Barreiro, E; Martín-Ontiyuelo, C

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Abstract

We hypothesized that a rise in the levels of oxidative/nitrosative stress markers and a decline in antioxidants might take place in systemic and muscle compartments of chronic obstructive pulmonary disease (COPD) patients with non-anemic iron deficiency. In COPD patients with/without iron depletion (n = 20/group), markers of oxidative/nitrosative stress and antioxidants were determined in blood and vastus lateralis (biopsies, muscle fiber phenotype). Iron metabolism, exercise, and limb muscle strength were assessed in all patients. In iron-deficient COPD compared to non-iron deficient patients, oxidative (lipofuscin) and nitrosative stress levels were greater in muscle and blood compartments and proportions of fast-twitch fibers, whereas levels of mitochondrial superoxide dismutase (SOD) and Trolox equivalent antioxidant capacity (TEAC) decreased. In severe COPD, nitrosative stress and reduced antioxidant capacity were demonstrated in vastus lateralis and systemic compartments of iron-deficient patients. The slow- to fast-twitch muscle fiber switch towards a less resistant phenotype was significantly more prominent in muscles of these patients. Iron deficiency is associated with a specific pattern of nitrosative and oxidative stress and reduced antioxidant capacity in severe COPD irrespective of quadriceps muscle function. In clinical settings, parameters of iron metabolism and content should be routinely quantify given its implications in redox balance and exercise tolerance. © 2023 by the authors.

Keywords

AdultAnalytical parametersAntigen retrievalAntioxidantAntioxidant activityAntioxidant systemsAntioxidantsArticleBlood samplingBody massChronic obstructive lung diseaseClinical articleClinical assessmentControlled studyCopdDna strand breakageExerciseExercise toleranceFast muscle fiberFemaleForced expiratory volumeForced vital capacityGrip strengthHemoglobin determinationHumanHuman cellHumansImmunoblottingImmunohistochemistryInflammatory cellIronIron deficienciesIron deficiencyIron depletionIron metabolismLeg muscleLipofuscinLipofuscin inclusionsLung functionMaleMean corpuscular hemoglobinMean corpuscular hemoglobin concentrationMetabolismMolecular weightMuscle and systemic compartmentsMuscle biopsyMuscle cellMuscle fiber type switchMuscle functionMuscle strengthMuscle trainingMuscle twitchNitrosative stressNon-anemic iron deficiencyOptical densityOxidation reduction reactionOxidative stressProtein carbonylationProtein contentPulmonary disease, chronic obstructiveQuadriceps femoris muscleQuadriceps muscleQuantitative analysisRoom temperatureSkeletal muscle cellSlow muscle fiberSuperoxide dismutaseTrolox equivalent antioxidant capacityTunel assayVastus lateralis muscle

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 18/114, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.13, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-04, the following number of citations:

  • Scopus: 2
  • OpenCitations: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 16.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.