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Analysis of institutional authors

Llach JAuthorAguilera PAuthorSanchez AAuthorGines AAuthorFernández-Esparrach GAuthorSoy GAuthorSendino OAuthorVaquero EAuthorCarballal SAuthorAusania FAuthorAyuso JrAuthorPellise MAuthorCastellvi-Bel SAuthorPuig SAuthorBalaguer FAuthorMoreira LCorresponding Author

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March 30, 2023
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Pancreatic Cancer Surveillance in Carriers of a Germline Pathogenic Variant in CDKN2A

Publicated to: Cancers. 15 (6): 1690- - 2023-03-01 15(6), DOI: 10.3390/cancers15061690

Authors:

Llach, Joan; Aguilera, Paula; Sanchez, Ariadna; Gines, Angels; Fernandez-Esparrach, Gloria; Soy, Guillem; Sendino, Oriol; Vaquero, Eva; Carballal, Sabela; Ausania, Fabio; Ramon Ayuso, Juan; Darnell, Anna; Pellise, Maria; Castellvi-Bel, Sergi; Puig, Susana; Balaguer, Francesc; Moreira, Leticia
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Affiliations

Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), 08036 Barcelona, Spain. - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Raras - Author
Univ Barcelona UB, Fac Med & Ciencies Salut 1 - Author
Univ Barcelona UB, IDIBAPS Inst Invest Biomed August Pi & Sunyer - Author
Univ Barcelona, Hosp Clin Barcelona, Dept Gen & Digest Surg - Author
Univ Barcelona, Hosp Clin Barcelona, Dept Radiol - Author
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Abstract

Three percent of patients with pancreatic ductal adenocarcinoma (PDAC) present a germline pathogenic variant (GPV) associated with an increased risk of this tumor, CDKN2A being one of the genes associated with the highest risk. There is no clear consensus on the recommendations for surveillance in CDKN2A GPV carriers, although the latest guidelines from the International Cancer of the Pancreas Screening Consortium recommend annual endoscopic ultrasound (EUS) or magnetic resonance imaging (MRI) regardless of family history. Our aim is to describe the findings of the PDAC surveillance program in a cohort of healthy CDKN2A GPV heterozygotes. This is an observational analysis of prospectively collected data from all CDKN2A carriers who underwent screening for PDAC at the high-risk digestive cancer clinic of the “Hospital Clínic de Barcelona” between 2013 and 2021. A total of 78 subjects were included. EUS or MRI was performed annually with a median follow-up of 66 months. Up to 17 pancreatic findings were described in 16 (20.5%) individuals under surveillance, although most of them were benign. No significant precursor lesions were identified, but an early PDAC was detected and treated. While better preventive strategies are developed, we believe that annual surveillance with EUS and/or MRI in CDKN2A GPV heterozygotes may be beneficial. © 2023 by the authors.
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Keywords

AdultAlcohol consumptionArticleCancer epidemiologyCancer stagingCause of deathCdkn2aCohort analysisCyclin dependent kinase 4Cyclin dependent kinase inhibitor 2aEndoscopic ultrasonographyEnvironmental riskFemaleFine needle aspiration biopsyFollow upGenetic screeningGerm lineHereditaryHistologyHumanIntraductal papillary mucinous tumorJaundiceLiver metastasisMajor clinical studyMaleMelanomaMucinous cystadenomaNeoadjuvant chemotherapyNeuroendocrine tumorNon insulin dependent diabetes mellitusNuclear magnetic resonance imagingObservational studyPancreas cancerPancreatectomyPancreatic cancerPancreatic ductPancreatic ductal carcinomaRisk factorSmokingSplenectomySurveillance

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cancers due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 78/322, thus managing to position itself as a Q1 (Primer Cuartil), in the category Oncology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.27. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-10, the following number of citations:

  • WoS: 7
  • Scopus: 7
  • Europe PMC: 6
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-10:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 11.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Llach Vila, Josep) and Last Author (Moreira Ruiz, Leticia).

the author responsible for correspondence tasks has been Moreira Ruiz, Leticia.

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