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Analysis of institutional authors

Ramos-Triguero AAuthorGarcía-Algar OAuthor

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May 29, 2023
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Article

Effect of Postnatal Epigallocatechin-Gallate Treatment on Cardiac Function in Mice Prenatally Exposed to Alcohol

Publicated to: Antioxidants. 12 (5): 1067- - 2023-05-09 12(5), DOI: 10.3390/antiox12051067

Authors:

Andreu-Fernández, V; Serra-Delgado, M; Almeida-Toledano, L; García-Meseguer, A; Vieiros, M; Ramos-Triguero, A; Muñoz-Lozano, C; Navarro-Tapia, E; Martínez, L; García-Algar, O; Gómez-Roig, MD
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Affiliations

Department of Neonatology, Hospital Clínic-Maternitat, ICGON, IDIBAPS, BCNatal, 08028 Barcelona, Spain. - Author
Department of Pediatric Surgery, Hospital Universitario La Paz, 28046 Madrid, Spain. - Author
Grup de Recerca Infancia i Entorn (GRIE), Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain. - Author
Hosp Clin Maternitat, Dept Neonatol, ICGON, IDIBAPS,BCNatal - Author
Hosp Univ La Paz, Dept Pediat Surg - Author
Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain. - Author
Univ Barcelona, Hosp St Joan De Deu & Hosp Clin, Barcelona Ctr Maternal Fetal & Neonatal Med - Author
Valencian Int Univ VIU, Biosanit Res Inst - Author
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Abstract

Prenatal alcohol exposure affects the cardiovascular health of the offspring. Epigallocatechin-3-gallate (EGCG) may be a protective agent against it, but no data are available regarding its impact on cardiac dysfunction. We investigated the presence of cardiac alterations in mice prenatally exposed to alcohol and the effect of postnatal EGCG treatment on cardiac function and related biochemical pathways. C57BL/6J pregnant mice received 1.5 g/kg/day (Mediterranean pattern), 4.5 g/kg/day (binge pattern) of ethanol, or maltodextrin until Day 19 of pregnancy. Post-delivery, treatment groups received EGCG-supplemented water. At post-natal Day 60, functional echocardiographies were performed. Heart biomarkers of apoptosis, oxidative stress, and cardiac damage were analyzed by Western blot. BNP and Hif1α increased and Nrf2 decreased in mice prenatally exposed to the Mediterranean alcohol pattern. Bcl-2 was downregulated in the binge PAE drinking pattern. Troponin I, glutathione peroxidase, and Bax increased in both ethanol exposure patterns. Prenatal alcohol exposure led to cardiac dysfunction in exposed mice, evidenced by a reduced ejection fraction, left ventricle posterior wall thickness at diastole, and Tei index. EGCG postnatal therapy restored the physiological levels of these biomarkers and improved cardiac dysfunction. These findings suggest that postnatal EGCG treatment attenuates the cardiac damage caused by prenatal alcohol exposure in the offspring. © 2023 by the authors.
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Keywords

AlcoholAlcoholism in pregnancyAlcoholisme en l'embaràsAntioxidantsApoptosisBinge alcohol drinking patternCardiovascular diseasesEchocardiographyEpigallocatechin-3-gallate (egcg)Estrès oxidatiuFasd-like mouse modelHeartMalalties cardiovascularsMares i fillsModerate alcohol drinking patternMother and childNatural antioxidantsOxidative stressPrenatal alcohol exposure (pae)

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 8/72, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-01:

  • WoS: 6
  • Scopus: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 13.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 13 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2445/213381
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Andreu-Fernández V) .

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