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Analysis of institutional authors

Casas RAuthorBartra JAuthorTorres MjAuthor

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August 21, 2023
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Different patterns of response in hypersensitivity reactions to arylpropionic acid derivatives

Publicated to: Journal Of Allergy And Clinical Immunology-In Practice. 11 (12): 3715-3723 - 2023-12-06 11(12), DOI: 10.1016/j.jaip.2023.08.014

Authors:

Salas-Casinello, M; María, RSD; López-Sánchez, JD; Cornejo-Garcia, JA; Pérez-Sánchez, N; Casas, R; Bartra, J; Laguna, JJ; Cortés-Collado, JJ; Doña, I; Torres, MJ
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Affiliations

Allergy Department, Virgen de la Arrixaca Clinical University Hospital. Murcia, Spain. - Author
Allergy Department, Virgen de la Arrixaca Clinical University Hospital. Murcia, Spain. Electronic address: inmadd@hotmail.com. - Author
Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA.Malaga, Spain - Author
Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA.Malaga, Spain. - Author
Allergy Section, Pneumology Department, IDIBAPS, Universitat de Barcelona, Hospital Clinic. Barcelona, Spain. - Author
Allergy Unit, Hospital Central de la Cruz Roja. Madrid, Spain. - Author
Allergy Unit, Hospital Regional Universitario de Málaga. Malaga, Spain - Author
Hosp Cent Cruz Roja, Allergy Unit, Madrid, Spain - Author
Hosp Reg Univ Malaga, Allergy Unit, Malaga, Spain - Author
Hosp Reg Univ Malaga, Allergy Unit, Pabellon 6,Primera Planta,Pabellon C,Plaza Hosp Ci, Malaga 29009, Spain - Author
Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain - Author
Medicine Department, Universidad de Málaga. Malaga, Spain. - Author
Spanish Network Allergy RETICS Asma Reacc Adversas, Madrid, Spain - Author
Spanish Network for Allergy-RETICS de Asma, Reacciones adversas y Alérgicas(ARADyAL). Madrid, Spain - Author
Spanish Network for Allergy-RETICS de Asma, Reacciones adversas y Alérgicas(ARADyAL). Madrid, Spain. - Author
Univ Barcelona, Hosp Clin, Pneumol Dept, Allergy Sect,IDIBAPS, Barcelona, Spain - Author
Univ Malaga, Med Dept, Malaga, Spain - Author
Virgen Arrixaca Clin Univ Hosp, Allergy Dept, Murcia, Spain - Author
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Abstract

Ibuprofen and other arylpropionic acid derivatives (APs) are among the most consumed non-steroidal anti-inflammatory drugs (NSAIDs) worldwide at all age ranges; however, little is known about drug hypersensitivity reactions (DHRs) they induce.Our aim was to characterize in detail patients reporting DHRs to APs.We prospectively evaluated patients with symptoms suggestive of AP-DHRs and analyzed their clinical characteristics, reported reactions, and diagnostic approaches.Six hundred and sixty-two patients confirmed as hypersensitive to APs were included: 489 with cross-reactive reactions (CRs) (73.86%) and 173 with selective reactions (SRs) (26.13%). The percentage of subjects reporting reactions to ibuprofen and dexketoprofen was higher in CRs (p=0.005 and p=0.01, respectively), whereas naproxen and ketoprofen were more frequently involved in SRs (p=0.0002 and p=0.00001, respectively). The most frequent symptoms induced by ibuprofen, dexketoprofen, and naproxen were isolated angioedema and urticaria, combined or not with angioedema in both CRs and SRs. Nasal provocation test with lysine acetylsalicylate was positive in 156 cases (77.14% in patients showing exclusively respiratory symptoms, and in 68.18% of those with both cutaneous and respiratory involvement). To confirm diagnosis, drug provocation test (DPT) with acetylsalicylic acid was required in 246 CR patients (50.3%), whereas in 28 SR patients (16.18%) DPT with the culprit AP was required.Skin is the organ most commonly involved in AP-DHRs, with ibuprofen and dexketoprofen inducing most frequently CRs, and naproxen and ketoprofen SRs. More studies are necessary to clarify the underlying mechanism in DHRs induced by APs.Copyright © 2023. Published by Elsevier Inc.
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Keywords

AdultAnaphylaxisAngioedemaAngioneurotic edemaAnti-inflammatory agents, non-steroidalArticleArylpropionic acid derivativeAsthmaClinical evaluationClinical featureContact dermatitisControlled studyDexketoprofenDrug hypersensitivityDrug provocation testDrug safetyFemaleFixed drug eruptionHumanHumansHypersensitivityIbuprofenKetoprofenMaculopapular rashMajor clinical studyMaleMedical historyNaproxenNon-steroidal anti-inflammatory drugs (nsaids)Nonsteroid antiinflammatory agentNonsteroidal anti-inflammatory drugs (nsaids)Nose provocation testProspective studyRespiratory tract diseaseRhinitisSkin diseaseStevens johnson syndromeUrticaria

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Allergy And Clinical Immunology-In Practice due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 4/39, thus managing to position itself as a Q1 (Primer Cuartil), in the category Allergy. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.01. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-01-12, the following number of citations:

  • WoS: 5
  • Scopus: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-12:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 6.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Torres de Dalmases, Carme).

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