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Analysis of institutional authors

Roca-Ferrer JCorresponding AuthorPerez-Gonzalez MAuthorAlobid IAuthorTubita VAuthorFuentes MAuthorBantulà MAuthorMunoz-Cano RAuthorValero AAuthorMullol JCorresponding Author

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December 22, 2023
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Upregulation of Platelet-Activating Factor Receptor Expression and Lyso-Platelet-Activating Factor Isoforms in Human Nasal Polyp Tissues

Publicated to: Journal Of Clinical Medicine. 12 (23): 7357- - 2023-12-01 12(23), DOI: 10.3390/jcm12237357

Authors:

Roca-Ferrer, J; Perez-Gonzalez, M; Alobid, I; Tubita, V; Fuentes, M; Bantula, M; Munoz-Cano, R; Valero, A; Izquierdo, I; Mullol, J; Galli, J
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Affiliations

August Pi Sunyer Biomed Res Inst FRCB IDIBAPS, Clin Fdn Biomed Res, Clin & Expt Resp Immunoallergy IRCE, Barcelona 08036, Spain - Author
Hlth Inst Carlos III, CIBER Resp Dis CIBERES, Madrid 28029, Spain - Author
Hosp Clin Barcelona, ENT Dept, Rhinol Unit, Barcelona 08036, Spain - Author
Hosp Clin Barcelona, ENT Dept, Smell Clin, Barcelona 08036, Spain - Author
NOUCOR, Clin Dev & Med Advise, R&D, Palau de Plegamans 08184, Spain - Author
Univ Barcelona, Fac Med, Barcelona 08036, Spain - Author
Univ Barcelona, Hosp Clin, Allergy Dept, Barcelona 08036, Spain - Author
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Abstract

Background: The Platelet-Activating Factor (PAF)/receptor (PAFR) system is involved in asthma and allergic rhinitis; however, its role in chronic rhinosinusitis (CRS) is still unclear. This study aimed to assess the expression of PAFR and the concentration of Lyso-PAF isoforms in the nasal polyps (NP) of patients suffering from CRS with/without comorbidities such as asthma and NSAID-exacerbated respiratory disease (N-ERD) compared to healthy nasal mucosa (NM) from control subjects. Methods: NM (n = 8) and NP tissues were obtained from patients undergoing surgery for septal deviation/turbinate hypertrophy or endoscopic sinus surgery, respectively. Three phenotypes were studied: CRSwNP with no asthma (n = 6), CRSwNP with non-steroidal anti-inflammatory drug (NSAID)-tolerant asthma (n = 6), and CRSwNP with NSAID-exacerbated respiratory disease (n = 6). PAFR protein and mRNA were assessed via immunochemistry, immunofluorescence, Western blot, and real-time quantitative PCR. Lyso-PAF isoforms (C16, C18, and C18:1) were quantified via mass spectrometry. Results: PAFR protein was expressed in the NM and NP, concretely in epithelial cells and submucosal glands. Compared to NM, PAFR mRNA expression was higher in all NP phenotypes (p < 0.05) while all Lyso-PAF isoform concentrations were higher in the NP from asthmatic patients (p < 0.05). Lyso-PAF C16 and C18 concentrations were higher in the NP from asthmatic patients than in the NP from patients without asthma. Conclusions: The PAF/PAFR system could play a pathophysiological role in CRSwNP pathogenesis.
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Keywords

1 o alkylglycero 3 phosphorylcholineAdultAllergic rhinitisAllergic rhinitis,paf,challengArticleAsthmaChronic inflammationChronic rhinosinusitisChronic rhinosinusitis with nasal polypsControlled studyEndoscopic sinus surgeryFemaleGene expressionHumanHuman cellHuman tissueImmunochemistryImmunofluorescenceImmunohistochemistryLyso-pafMajor clinical studyMaleMass spectrometryMiddle agedNonsteroid antiinflammatory agentNose mucosaNsaid-exacerbated respiratory diseaseOral drug administrationPlatelet-activating factorPlatelet-activating factor receptorPlatelet-activating factor,platelet-activating factor receptor,chronic rhinosinusitis with nasal polyps,asthma,nsaid-exacerbated respiratory disease,lyso-paPolypReal time polymerase chain reactionRespiratory tract diseaseSignal transductionSinonasal polypThrombocyte activating factorThrombocyte activating factor receptorUpper respiratory tractUpregulationWestern blotting

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Clinical Medicine due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 59/329, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, General & Internal.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-02:

  • WoS: 2
  • Scopus: 2
  • Europe PMC: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Palau.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Roca Ferrer, Jordi) and Last Author (Mullol i Miret, Joaquim).

the authors responsible for correspondence tasks have been Roca Ferrer, Jordi and Mullol i Miret, Joaquim.

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Awards linked to the item

This study has been funded by a research grant from the NOUCOR/Uriach Group (08184-Palau Solitai Plegamans, Spain) with funding number RINOPAF-1
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