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Grant support

This research was supported by the Sao Paulo Research Foundation - FAPESP [grant numbers 17/21155-3, 19/02787-4, 19/05957-8, 19/165742, 19/00849-2, and 2021/13622-6], the National Institutes for Science and Technology (INCT) - "Translational Medicine", FAPESP [grant numbers 14/50891-1], National Council for Scientific and Technological Development (CNPq) [grant numbers 2022-2952, 305883/2014-3 and 465458/2014-9], Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) - Finance Code 001, and Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior - PROEX-CAPES. NGC holds a CNPq 1A Research Fellowship.

Analysis of institutional authors

Patricio Da Silva Junior, Rui MiltonAuthor
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Article

Audiogenic Seizures in the Streptozotocin-Induced Rat Alzheimer's Disease Model

Publicated to:Journal Of Alzheimers Disease. 94 (3): 1179-1196 - 2023-01-01 94(3), DOI: 10.3233/JAD-230153

Authors: Alves, Suelen Santos; Antonio Cortes de Oliveira, Jose; Lazarini-Lopes, Willian; Servilha-Menezes, Gabriel; Grigorio-de-Sant'Ana, Mariana; Del Vecchio, Flavio; Focosi Mazzei, Rodrigo; Sousa Almeida, Sebastiao; Milton Patricio da Silva Junior, Rui; Garcia-Cairasco, Norberto

Affiliations

Univ Sao Paulo FMRP USP, Dept Neurosci & Behav Sci, Ribeirao Preto Med Sch, Sao Paulo, SP, Brazil - Author
Univ Sao Paulo FMRP USP, Dept Physiol, Ribeirao Preto Med Sch, Sao Paulo, Brazil - Author

Abstract

Background: Alzheimer's disease (AD) is a neurodegenerative and progressive disorder with no cure and constant failures in clinical trials. The main AD hallmarks are amyloid-beta (A beta) plaques, neurofibrillary tangles, and neurodegeneration. However, many other events have been implicated in AD pathogenesis. Epilepsy is a common comorbidity of AD and there is important evidence indicating a bidirectional link between these two disorders. Some studies suggest that disturbed insulin signaling might play an important role in this connection. Objective: To understand the effects of neuronal insulin resistance in the AD-epilepsy link. Methods: We submitted the streptozotocin (STZ) induced rat AD Model (icv-STZ AD) to an acute acoustic stimulus (AS), a known trigger of seizures. We also assessed animals' performance in the memory test, the Morris water maze and the neuronal activity (c-Fos protein) induced by a single audiogenic seizure in regions that express high levels of insulin receptors. Results: We identified significant memory impairment and seizures in 71.43% of all icv-STZ/AS rats, in contrast to 22.22% of the vehicle group. After seizures, icv-STZ/AS rats presented higher number of c-Fos immunopositive cells in hippocampal, cortical, and hypothalamic regions. Conclusion: STZ may facilitate seizure generation and propagation by impairment of neuronal function, especially in regions that express high levels of insulin receptors. The data presented here indicate that the icv-STZ AD model might have implications not only for AD, but also for epilepsy. Finally, impaired insulin signaling might be one of the mechanisms by which AD presents a bidirectional connection to epilepsy.

Keywords
alzheimer's diseaseepilepsyhyperphosphorylated tauinferior colliculusinsulin resistanceinsulin-resistancememorymemory impairmentmouse modeloxidative stressseizuresstreptozotocinsubstantia-nigratherapeutic strategieswater-mazeAcoustic stimulusC-fos expression

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Alzheimers Disease due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.1, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-10, the following number of citations:

  • WoS: 3
  • Scopus: 3
  • OpenCitations: 1
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-10:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 12.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Brazil.